| Gene Symbol |
CADM3
|
| Entrez Gene |
57863
|
| Alt Symbol |
BIgR, IGSF4B, NECL1, Necl-1, TSLL1, synCAM3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
cell adhesion molecule 3
|
| Other Description |
TSLC1-like 1|TSLC1-like protein 1|brain immunoglobulin receptor|dendritic cell nectin-like protein 1 short isoform|immunoglobulin superfamily member 4B|immunoglobulin superfamily, member 4B|nectin-like 1|nectin-like protein 1|synaptic cell adhesion molecule 3
|
| Swissprots |
Q8IZQ9 Q9NVJ5 Q9UJP1 Q8N126
|
| Accessions |
AAU47274 AAU47277 AAU47280 AAU47283 AAU47286 AAU47289 AAU47292 AAU47295 AAU47298 AAU47301 AAU47304 AAU47307 AAU47310 AAU47313 AAU47316 AAU47319 AAU47322 AAU47325 ABA10402 ABA10405 ABA10408 ABA10411 ABA10414 ABA10417 ABA10420 ABA10423 ABA10426 ABA10429 ABA10432 ABA10435 ABA10438 ABA10441 ABA10444 CAI58844 CAI58845 CBI85482 CBI85483 EAW52792 EAW52793 EAW52794 Q8N126 AF062733 AAD17540 AF363367 AAM60749 AF529206 AAN75603 AK001560 BAA91756 AK289541 BAF82230 AK308915 AY046418 AAL02143 AY358332 AAQ88698 BC033819 AAH33819 DQ890848 ABM81774 DQ894002 ABM84928 NM_001127173 NP_001120645 NM_021189 NP_067012
|
| Function |
Involved in the cell-cell adhesion. Has both calcium- independent homophilic cell-cell adhesion activity and calcium- independent heterophilic cell-cell adhesion activity with IGSF4, PVRL1 and PVRL3. Interaction with EPB41L1 may regulate structure or function of cell-cell junctions (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cell junction {ECO:0000250}. Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Note=Localized at the cell-cell attached sites of the plasma membrane. {ECO:0000250}.
|
| Tissue Specificity |
Isoform 1 is expressed mainly in adult and fetal brain. Isoform 2 is highly expressed in adult brain and weakly expressed in placenta. In brain, Isoform 2 is highly expressed in cerebellum. {ECO:0000269|PubMed:11536053, ECO:0000269|PubMed:15893517, ECO:0000269|PubMed:18420026}.
|
| Top Pathways |
Cell adhesion molecules (CAMs)
|