| Gene Symbol | BAG1 |
|---|---|
| Entrez Gene | 573 |
| Alt Symbol | BAG-1, HAP, RAP46 |
| Species | Human |
| Gene Type | protein-coding |
| Description | BCL2-associated athanogene |
| Other Description | BAG family molecular chaperone regulator 1|Bcl-2 associating athanogene-1 protein|Bcl-2-binding protein|glucocortoid receptor-associated protein RAP46|receptor-associated protein, 46-KD |
| Swissprots | Q53H32 Q14414 Q9Y2V4 Q5VZF0 Q5VZE8 O75315 Q99933 Q96TG2 Q5VZE9 |
| Accessions | EAW58514 EAW58515 EAW58516 EAW58517 Q99933 AF022224 AAC34258 AF116273 AAD25045 AK093238 AK096038 AK222749 BAD96469 AK316577 AM392568 CAL37446 BC001936 AAH01936 BC014774 AAH14774 BG723775 CN478628 U46917 AAD11467 Z35491 CAA84624 NM_001172415 NP_001165886 NM_004323 NP_004314 |
| Function | Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Inhibits the pro-apoptotic function of PPP1R15A, and has anti-apoptotic activity. Markedly increases the anti-cell death function of BCL2 induced by various stimuli. {ECO:0000269|PubMed:12724406, ECO:0000269|PubMed:9305631, ECO:0000269|PubMed:9873016}. |
| Subcellular Location | Isoform 4: Cytoplasm. Nucleus. Note=Isoform 4 localizes predominantly to the cytoplasm. The cellular background in which it is expressed can influence whether it resides primarily in the cytoplasm or is also found in the nucleus. In the presence of BCL2, localizes to intracellular membranes (what appears to be the nuclear envelope and perinuclear membranes) as well as punctate cytosolic structures suggestive of mitochondria. |
| Tissue Specificity | Isoform 4 is the most abundantly expressed isoform. It is ubiquitously expressed throughout most tissues, except the liver, colon, breast and uterine myometrium. Isoform 1 is expressed in the ovary and testis. Isoform 4 is expressed in several types of tumor cell lines, and at consistently high levels in leukemia and lymphoma cell lines. Isoform 1 is expressed in the prostate, breast and leukemia cell lines. Isoform 3 is the least abundant isoform in tumor cell lines (at protein level). {ECO:0000269|PubMed:9679980}. |
| Top Pathways | Protein processing in endoplasmic reticulum |