CASQ1

Gene Symbol	CASQ1
Entrez Gene	844
Alt Symbol	CASQ, PDIB1, VMCQA
Species	Human
Gene Type	protein-coding
Description	calsequestrin 1 (fast-twitch, skeletal muscle)
Other Description	calmitin|calmitine|calsequestrin, skeletal muscle isoform|calsequestrin-1
Swissprots	Q8TBW7 B1AKZ2 P31415 B2R863
Accessions	EAW52736 P31415 AA197256 AI141895 AK300713 BAG62390 AK313250 BAG36060 BC022289 AAH22289 BF574316 BX500008 DA766051 DQ891985 ABM82911 DQ895175 ABM86101 S73775 AAB32063 NM_001231 NP_001222
Function	Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle. Calcium ions are bound by clusters of acidic residues at the protein surface, often at the interface between subunits. Can bind around 80 Ca(2+) ions. Regulates the release of lumenal Ca(2+) via the calcium release channel RYR1; this plays an important role in triggering muscle contraction. {ECO:0000269|PubMed:22337878, ECO:0000303|PubMed:22337878}.
Subcellular Location	Sarcoplasmic reticulum lumen {ECO:0000250|UniProtKB:P07221}. Sarcoplasmic reticulum membrane; Peripheral membrane protein; Lumenal side {ECO:0000250|UniProtKB:P07221}. Mitochondrion matrix {ECO:0000250|UniProtKB:O09165}. Note=This isoform of calsequestrin occurs in the sarcoplasmic reticulum's terminal cisternae luminal spaces of fast skeletal muscle cells. {ECO:0000250|UniProtKB:P07221}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

calsequestrin 1 CRISPR/Cas9 KO Plasmid (h) - sc-403375 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

calsequestrin 1 HDR Plasmid (h) - sc-403375-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

calsequestrin 1 Double Nickase Plasmid (h) - sc-403375-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

calsequestrin 1 Double Nickase Plasmid (h2) - sc-403375-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

calsequestrin 1 CRISPR Activation Plasmid (h) - sc-403375-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

calsequestrin 1 CRISPR Activation Plasmid (h2) - sc-403375-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

calsequestrin 1 Lentiviral Activation Particles (h) - sc-403375-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

calsequestrin 1 Lentiviral Activation Particles (h2) - sc-403375-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

calsequestrin 1 siRNA (h) - sc-43275 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

calsequestrin 1 shRNA Plasmid (h) - sc-43275-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

calsequestrin 1 shRNA (h) Lentiviral Particles - sc-43275-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

MISSION® esiRNA - EHU003181 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN5390 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND5390 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR04239 from Sigma-Aldrich Category miRNA Prices $350.00 Sizes hutr04239

CASQ1 siRNA (Human) - CRH0598 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

Calsequestrin 1 RNAi - H00000844-R01 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

CASQ1 - MBS8227290 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

calsequestrin 1 HDR Plasmid (h2) - sc-403375-HDR-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

calsequestrin 1 CRISPR/Cas9 KO Plasmid (h2) - sc-403375-KO-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

shRNA set against Human CASQ1 (NM_001231.4) - SHH255061 from Creative biogene Category siRNA Species Reactivities Human

Human CASQ1 siRNA - orb261100 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

CASQ1 shRNA Plasmid (Human) - CHH0598 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

CASQ1 miRNA 3'UTR clone - MiUTR3H-00337 from Creative biogene Species Reactivities Human

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