| Gene Symbol | Gabrg2 |
|---|---|
| Entrez Gene | 14406 |
| Alt Symbol | GABAA-R, Gabrg-2, gamma2 |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2 |
| Other Description | gamma-aminobutyric acid receptor subunit gamma-2 |
| Swissprots | Q91VA8 P22723 Q91V50 |
| Accessions | EDL32338 EDL32339 EDL32340 P22723 AF233775 AAK71573 AF233776 AAK71574 AF233777 AAK71575 AF233778 AAK71576 AF233779 AAK71577 AF233780 AAK71578 AF233781 AAK71579 AF233782 AAK71580 AF233783 AAK71581 AF233784 AAK71582 AF233785 AAK71583 AF233786 AAK71584 AF233787 AAK71585 AF233788 AAK71586 AF233789 AAK71587 AF233790 AAK71588 AF233791 AAK71589 AF233792 AAK71590 AF233793 AAK71591 AF233794 AAK71592 AF233795 AAK71593 AF233796 AAK71594 AF233797 AAK71595 AF233798 AAK71596 AF233799 AAK71597 AF233800 AAK71598 AF233801 AAK71599 AF233802 AAK71600 AK034338 AK047085 BAC32956 AK049857 BAC33961 AK078261 AK136889 BAE23157 AK141129 BC031762 AAH31762 M62374 AAA37653 M86572 AAB59635 X56311 X56313 XM_006532199 XP_006532262 XM_006532200 XP_006532263 NM_008073 NP_032099 NM_177408 NP_803127 |
| Function | Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand- gated chloride channel. {ECO:0000269|PubMed:18281286}. |
| Subcellular Location | Cell junction, synapse, postsynaptic cell membrane {ECO:0000269|PubMed:18281286}; Multi-pass membrane protein {ECO:0000269|PubMed:18281286}. Cell membrane {ECO:0000269|PubMed:18281286}; Multi-pass membrane protein {ECO:0000269|PubMed:18281286}. |
| Top Pathways | GABAergic synapse, Morphine addiction, Nicotine addiction, Retrograde endocannabinoid signaling, Neuroactive ligand-receptor interaction |
GABA A Rγ2 CRISPR/Cas9 KO Plasmid (m) - sc-420464 from Santa Cruz Biotechnology
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GABA A Rγ2 HDR Plasmid (m) - sc-420464-HDR from Santa Cruz Biotechnology
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GABA A Rγ2 Double Nickase Plasmid (m) - sc-420464-NIC from Santa Cruz Biotechnology
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GABA A Rγ2 Double Nickase Plasmid (m2) - sc-420464-NIC-2 from Santa Cruz Biotechnology
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GABA A Rγ2 CRISPR Activation Plasmid (m) - sc-420464-ACT from Santa Cruz Biotechnology
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GABA A Rγ2 CRISPR Activation Plasmid (m2) - sc-420464-ACT-2 from Santa Cruz Biotechnology
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GABA A Rγ2 Lentiviral Activation Particles (m) - sc-420464-LAC from Santa Cruz Biotechnology
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GABA A Rγ2 Lentiviral Activation Particles (m2) - sc-420464-LAC-2 from Santa Cruz Biotechnology
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GABA A Rγ2 siRNA (m) - sc-42450 from Santa Cruz Biotechnology
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GABA A Rγ2 shRNA Plasmid (m) - sc-42450-SH from Santa Cruz Biotechnology
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GABA A Rγ2 shRNA (m) Lentiviral Particles - sc-42450-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN31673 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND31673 from Sigma-Aldrich
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GABRG2 siRNA (Mouse) - CRM1472 from Cohesion Biosciences
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GABRG2 - MBS8240549 from MyBioSource
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shRNA set against Mouse GABRG2 (NM_008073.2) - SHH298585 from Creative biogene
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shRNA set against Mouse Gabrg2(NM_008073.2) - SHH074431 from Creative biogene
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shRNA set against Mouse Gabrg2(NM_177408.5) - SHH074467 from Creative biogene
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Mouse GABRG2 siRNA - orb280948 from Biorbyt
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GABRG2 shRNA Plasmid (Mouse) - CHM1472 from Cohesion Biosciences
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GABRG2 miRNA 3'UTR clone - MiUTR1M-04889 from Creative biogene
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GABRG2 miRNA 3'UTR clone - MiUTR1M-04890 from Creative biogene
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