Gene Symbol | POU3F2 |
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Entrez Gene | 5454 |
Alt Symbol | BRN2, N-Oct3, OCT7, OTF-7, OTF7, POUF3, brn-2, oct-7 |
Species | Human |
Gene Type | protein-coding |
Description | POU class 3 homeobox 2 |
Other Description | POU domain, class 3, transcription factor 2|brain-2|brain-specific homeobox/POU domain protein 2|nervous system-specific octamer-binding transcription factor N-Oct-3|octamer-binding protein 7|octamer-binding transcription factor 7 |
Swissprots | Q9UJL0 Q14960 Q86V54 P20265 |
Accessions | AAB59611 EAW48491 P20265 AK095588 BAG53090 BC051699 AAH51699 BQ423615 BU183021 DA491157 Z11933 CAA77990 NM_005604 NP_005595 |
Function | Transcription factor that binds preferentially to the recognition sequence which consists of two distinct half-sites, ('GCAT') and ('TAAT'), separated by a nonconserved spacer region of 0, 2, or 3 nucleotides. Positively regulates the genes under the control of corticotropin-releasing hormone (CRH) and CRH II promoters (By similarity). {ECO:0000250}. |
Subcellular Location | Nucleus. |
Tissue Specificity | Expressed specifically in the neuroectodermal cell lineage. |
Brn-2 CRISPR/Cas9 KO Plasmid (h) - sc-400392 from Santa Cruz Biotechnology
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Brn-2 HDR Plasmid (h) - sc-400392-HDR from Santa Cruz Biotechnology
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Brn-2 Double Nickase Plasmid (h) - sc-400392-NIC from Santa Cruz Biotechnology
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Brn-2 Double Nickase Plasmid (h2) - sc-400392-NIC-2 from Santa Cruz Biotechnology
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Brn-2 CRISPR Activation Plasmid (h) - sc-400392-ACT from Santa Cruz Biotechnology
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Brn-2 CRISPR Activation Plasmid (h2) - sc-400392-ACT-2 from Santa Cruz Biotechnology
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Brn-2 Lentiviral Activation Particles (h) - sc-400392-LAC from Santa Cruz Biotechnology
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Brn-2 Lentiviral Activation Particles (h2) - sc-400392-LAC-2 from Santa Cruz Biotechnology
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Brn-2 siRNA (h) - sc-29837 from Santa Cruz Biotechnology
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Brn-2 shRNA Plasmid (h) - sc-29837-SH from Santa Cruz Biotechnology
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Brn-2 shRNA (h) Lentiviral Particles - sc-29837-V from Santa Cruz Biotechnology
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POU3F2/OCT7 RNAi - H00005454-R01 from Novus Biologicals
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MISSION® esiRNA - EHU041781 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN17178 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17178 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR12945 from Sigma-Aldrich
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POU3F2 siRNA (Human) - CRH3656 from Cohesion Biosciences
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Brn-2 CRISPR/Cas9 KO Plasmid (h2) - sc-400392-KO-2 from Santa Cruz Biotechnology
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Brn-2 HDR Plasmid (h2) - sc-400392-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human POU3F2 (NM_005604.3) - SHH380076 from Creative biogene
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Human POU3F2 siRNA - orb264158 from Biorbyt
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POU3F2 shRNA Plasmid (Human) - CHH3656 from Cohesion Biosciences
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