| Gene Symbol |
Lin7b
|
| Entrez Gene |
22342
|
| Alt Symbol |
LIN-7B, MALS-2, Veli2
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
lin-7 homolog B (C. elegans)
|
| Other Description |
lin 7 homolog b|mammalian lin-seven protein 2|protein lin-7 homolog B|veli-2|vertebrate homolog of C. elegans Lin-7 type 2|vertebrate lin-7 homolog 2
|
| Swissprots |
O88951
|
| Accessions |
EDL22844 O88951 AF087694 AAC78482 AF173082 AAD48501 AK019299 BC031780 AAH31780 NM_011698 NP_035828
|
| Function |
Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells. May increase the amplitude of ASIC3 acid-evoked currents by stabilizing the channel at the cell surface. {ECO:0000269|PubMed:15317815}.
|
| Subcellular Location |
Cell membrane {ECO:0000269|PubMed:15494546}; Peripheral membrane protein {ECO:0000269|PubMed:15494546}. Basolateral cell membrane {ECO:0000269|PubMed:15494546}; Peripheral membrane protein {ECO:0000269|PubMed:15494546}. Cell junction {ECO:0000269|PubMed:15494546}. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO:0000269|PubMed:15494546}; Peripheral membrane protein {ECO:0000269|PubMed:15494546}. Cell junction, tight junction {ECO:0000269|PubMed:15494546}. Cell junction, synapse, synaptosome {ECO:0000269|PubMed:15494546}. Note=Enriched in synaptosomes and at epithelial cell-cell junctions. Mainly basolateral in renal epithelial cells.
|
| Tissue Specificity |
Expressed in the kidney; predominantly in the vasa recta. {ECO:0000269|PubMed:11742811, ECO:0000269|PubMed:15494546}.
|