Gene Symbol | Unc45b |
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Entrez Gene | 217012 |
Alt Symbol | AA445617, Cmya4, D230041A13Rik, Unc45 |
Species | Mouse |
Gene Type | protein-coding |
Description | unc-45 homolog B (C. elegans) |
Other Description | UNC-45B|cardiomyopathy associated 4|protein unc-45 homolog B|striated muscle UNC45 |
Swissprots | Q8CGY6 Q8BHC5 Q8BWK3 Q5XG72 |
Accessions | EDL15684 Q8CGY6 AF539793 AAO13383 AK052294 BAC34921 AK081821 BAC38342 AK084418 BAC39178 AK168968 AK169274 BC084585 AAH84585 BY133112 NM_178680 NP_848795 |
Function | Acts as a co-chaperone for HSP90 and is required for proper folding of the myosin motor domain. Plays a role in sarcomere formation during muscle cell development. {ECO:0000269|PubMed:12356907, ECO:0000269|PubMed:18326487, ECO:0000269|PubMed:18478096}. |
Subcellular Location | Cytoplasm, cytosol {ECO:0000269|PubMed:18478096}. |
Tissue Specificity | Highly expressed in adult skeletal muscle and heart. Detected at intermediate levels in lung. Highly expressed in embryonic heart. {ECO:0000269|PubMed:12356907}. |
UNC45B CRISPR/Cas9 KO Plasmid (m) - sc-432156 from Santa Cruz Biotechnology
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UNC45B HDR Plasmid (m) - sc-432156-HDR from Santa Cruz Biotechnology
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UNC45B Double Nickase Plasmid (m) - sc-432156-NIC from Santa Cruz Biotechnology
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UNC45B Double Nickase Plasmid (m2) - sc-432156-NIC-2 from Santa Cruz Biotechnology
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UNC45B CRISPR Activation Plasmid (m) - sc-432156-ACT from Santa Cruz Biotechnology
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UNC45B CRISPR Activation Plasmid (m2) - sc-432156-ACT-2 from Santa Cruz Biotechnology
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UNC45B Lentiviral Activation Particles (m) - sc-432156-LAC from Santa Cruz Biotechnology
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UNC45B Lentiviral Activation Particles (m2) - sc-432156-LAC-2 from Santa Cruz Biotechnology
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UNC45B siRNA (m) - sc-154920 from Santa Cruz Biotechnology
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UNC45B shRNA Plasmid (m) - sc-154920-SH from Santa Cruz Biotechnology
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UNC45B shRNA (m) Lentiviral Particles - sc-154920-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN43939 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND43939 from Sigma-Aldrich
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UNC45B siRNA (Mouse) - CRN2093 from Cohesion Biosciences
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UNC45B - MBS8230947 from MyBioSource
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shRNA set against Mouse UNC45B (NM_178680.4) - SHH440540 from Creative biogene
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UNC45B shRNA Plasmid (Mouse) - CHN2093 from Cohesion Biosciences
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