| Gene Symbol | Ptpn6 |
|---|---|
| Entrez Gene | 116689 |
| Alt Symbol | Ptph6, Shp-1 |
| Species | Rat |
| Gene Type | protein-coding |
| Description | protein tyrosine phosphatase, non-receptor type 6 |
| Other Description | SH2 phosphatase 1|protein-tyrosine phosphatase SHP-1|tyrosine-protein phosphatase non-receptor type 6 |
| Swissprots | P81718 |
| Accessions | EDM01944 EDM01945 P81718 AF468653 AAL77056 BC099824 AAH99824 FQ232747 U77038 AAD00262 NM_053908 NP_446360 |
| Function | Modulates signaling by tyrosine phosphorylated cell surface receptors such as KIT and the EGF receptor/EGFR. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Together with MTUS1, induces UBE2V2 expression upon angiotensin II stimulation. Plays a key role in hematopoiesis. {ECO:0000269|PubMed:17068200}. |
| Subcellular Location | Cytoplasm {ECO:0000269|PubMed:17068200}. Nucleus {ECO:0000269|PubMed:17068200}. Note=In neurons, translocates into the nucleus after treatment with angiotensin II. Shuttles between the cytoplasm and nucleus via its association with PDPK (By similarity). {ECO:0000250}. |
| Top Pathways | Adherens junction, Jak-STAT signaling pathway, Natural killer cell mediated cytotoxicity, T cell receptor signaling pathway, B cell receptor signaling pathway |
Tyrosine-protein phosphatase non-receptor type 6 (PTPN6), Rat, ELISA Kit - CSB-EL019043RA from ARP American Research Products
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protein tyrosine phosphatase, non-receptor type 6, ELISA Kit - MBS931885 from MyBioSource
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Rat Tyrosine-protein phosphatase non-receptor type 6(PTPN6) ELISA kit - CSB-EL019043RA from Cusabio
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Rat Ptpn6 ELISA Kit - E094886 from Biobool
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PTPN6 ELISA Kit (Rat) (OKCA01011) - OKCA01011 from Aviva Systems Biology
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