Ptpn6

Gene Symbol Ptpn6
Entrez Gene 116689
Alt Symbol Ptph6, Shp-1
Species Rat
Gene Type protein-coding
Description protein tyrosine phosphatase, non-receptor type 6
Other Description SH2 phosphatase 1|protein-tyrosine phosphatase SHP-1|tyrosine-protein phosphatase non-receptor type 6
Swissprots P81718
Accessions EDM01944 EDM01945 P81718 AF468653 AAL77056 BC099824 AAH99824 FQ232747 U77038 AAD00262 NM_053908 NP_446360
Function Modulates signaling by tyrosine phosphorylated cell surface receptors such as KIT and the EGF receptor/EGFR. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Together with MTUS1, induces UBE2V2 expression upon angiotensin II stimulation. Plays a key role in hematopoiesis. {ECO:0000269|PubMed:17068200}.
Subcellular Location Cytoplasm {ECO:0000269|PubMed:17068200}. Nucleus {ECO:0000269|PubMed:17068200}. Note=In neurons, translocates into the nucleus after treatment with angiotensin II. Shuttles between the cytoplasm and nucleus via its association with PDPK (By similarity). {ECO:0000250}.
Top Pathways Adherens junction, Jak-STAT signaling pathway, Natural killer cell mediated cytotoxicity, T cell receptor signaling pathway, B cell receptor signaling pathway

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