Gene Symbol | CYP27B1 |
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Entrez Gene | 1594 |
Alt Symbol | CP2B, CYP1, CYP1alpha, CYP27B, P450c1, PDDR, VDD1, VDDR, VDDRI, VDR |
Species | Human |
Gene Type | protein-coding |
Description | cytochrome P450, family 27, subfamily B, polypeptide 1 |
Other Description | 1alpha(OH)ase|25 hydroxyvitamin D3-1-alpha hydroxylase|25-OHD-1 alpha-hydroxylase|25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial|VD3 1A hydroxylase|calcidiol 1-monooxygenase|cytochrome P450 subfamily XXVIIB polypeptide 1|cytochrome P450C1 alpha|cytochrome P450VD1-alpha|cytochrome p450 27B1 |
Swissprots | Q548T3 O15528 B2RC61 |
Accessions | AAC51854 AAD38325 AAG00416 AAM21669 AAP31972 BAA22657 BAA23418 BAM93575 EAW97067 O15528 AB005038 BAA23416 AB005989 BAA22656 AF020192 AAC51853 AF246895 AAF64299 AK314953 BAG37458 AW449645 BC001776 BC020267 BC136386 AAI36387 BP296031 DQ925362 DQ925363 DQ925364 DQ925365 DQ925366 DQ925367 DQ925368 DQ925369 DQ925370 DQ925371 NM_000785 NP_000776 |
Function | Catalyzes the conversion of 25-hydroxyvitamin D3 (25(OH)D) to 1-alpha,25-dihydroxyvitamin D3 (1,25(OH)2D) plays an important role in normal bone growth, calcium metabolism, and tissue differentiation. |
Subcellular Location | Mitochondrion membrane. |
Tissue Specificity | Kidney. |
Top Pathways | Tuberculosis, Steroid biosynthesis |
CYP27B1 CRISPR/Cas9 KO Plasmid (h) - sc-401155 from Santa Cruz Biotechnology
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CYP27B1 HDR Plasmid (h) - sc-401155-HDR from Santa Cruz Biotechnology
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CYP27B1 Double Nickase Plasmid (h) - sc-401155-NIC from Santa Cruz Biotechnology
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CYP27B1 Double Nickase Plasmid (h2) - sc-401155-NIC-2 from Santa Cruz Biotechnology
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CYP27B1 CRISPR Activation Plasmid (h) - sc-401155-ACT from Santa Cruz Biotechnology
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CYP27B1 CRISPR Activation Plasmid (h2) - sc-401155-ACT-2 from Santa Cruz Biotechnology
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CYP27B1 Lentiviral Activation Particles (h) - sc-401155-LAC from Santa Cruz Biotechnology
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CYP27B1 Lentiviral Activation Particles (h2) - sc-401155-LAC-2 from Santa Cruz Biotechnology
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CYP27B1 siRNA (h) - sc-60479 from Santa Cruz Biotechnology
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CYP27B1 shRNA Plasmid (h) - sc-60479-SH from Santa Cruz Biotechnology
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CYP27B1 shRNA (h) Lentiviral Particles - sc-60479-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU004761 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN1810 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1810 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR07086 from Sigma-Aldrich
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CYP27B1 siRNA (Human) - CRH1121 from Cohesion Biosciences
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CYP27B1 RNAi - H00001594-R01 from Novus Biologicals
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CYP27B1 - MBS8228803 from MyBioSource
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shRNA set against Human CYP27B1 (NM_000785.3) - SHH272981 from Creative biogene
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shRNA set against Human CYP27B1(NM_000785.3) - SHG215899 from Creative biogene
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CYP27B1 shRNA Plasmid (Human) - CHH1121 from Cohesion Biosciences
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CYP27B1 miRNA 3'UTR clone - MiUTR1H-02616 from Creative biogene
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