KCNE1

Gene Symbol KCNE1
Entrez Gene 3753
Alt Symbol ISK, JLNS, JLNS2, LQT2/5, LQT5, MinK
Species Human
Gene Type protein-coding
Description potassium channel, voltage gated subfamily E regulatory beta subunit 1
Other Description IKs producing slow voltage-gated potassium channel subunit beta Mink|cardiac delayed rectifier potassium channel protein|delayed rectifier potassium channel subunit IsK|minimal potassium channel|potassium voltage-gated channel subfamily E member 1|potassium voltage-gated channel, Isk-related family, member 1|potassium voltage-gated channel, Isk-related subfamily, member 1|voltage gated potassiun channel accessory subunit
Swissprots P15382 Q8N709 A5H1P2 Q91Z94
Accessions AAA36129 AAA63905 ABQ01238 ABS84249 ABS84252 EAX09783 P15382 AF135188 AAD25096 AI720140 AK095442 AK304336 BAG65181 AK311384 AK313543 BAG36319 AY789479 AAX11417 AY789480 AAX11418 BC036452 AAH36452 BC046224 AAH46224 BC069055 CD370857 CR541756 CAG46556 DA418828 DA806205 DB089177 DB214219 DB223354 DB230009 DB233067 EF514882 ABS84250 EF514883 ABS84251 EU008568 ABS31132 EU008569 ABS31133 EU008570 ABS31134 JF432567 ADZ15784 L28168 AAA58418 XM_011529555 XP_011527857 XM_011529556 XP_011527858 XM_011529557 XP_011527859 NM_000219 NP_000210 NM_001127668 NP_001121140 NM_001127669 NP_001121141 NM_001127670 NP_001121142 NM_001270402 NP_001257331 NM_001270403 NP_001257332 NM_001270404 NP_001257333 NM_001270405 NP_001257334
Function Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Assembled with KCNQ1/KVLQT1 is proposed to form the slowly activating delayed rectifier cardiac potassium (IKs) channel. The outward current reaches its steady state only after 50 seconds. Assembled with KCNH2/HERG may modulate the rapidly activating component of the delayed rectifying potassium current in heart (IKr).
Subcellular Location Membrane; Single-pass type I membrane protein.
Tissue Specificity Expressed in heart, lung, kidney, testis, ovaries, small intestine, peripheral blood leukocytes. Not detected in pancreas, spleen, prostate and colon. Restrictively localized in the apical membrane portion of epithelial cells. {ECO:0000269|PubMed:9312006}.
Top Pathways Adrenergic signaling in cardiomyocytes

KCNE1 CRISPR/Cas9 KO Plasmid (h) - sc-404317 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

KCNE1 HDR Plasmid (h) - sc-404317-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

KCNE1 Double Nickase Plasmid (h) - sc-404317-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

KCNE1 Double Nickase Plasmid (h2) - sc-404317-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

KCNE1 CRISPR Activation Plasmid (h) - sc-404317-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

KCNE1 CRISPR Activation Plasmid (h2) - sc-404317-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

KCNE1 Lentiviral Activation Particles (h) - sc-404317-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

KCNE1 Lentiviral Activation Particles (h2) - sc-404317-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

KCNE1 siRNA (h) - sc-42499 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

KCNE1 shRNA Plasmid (h) - sc-42499-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

KCNE1 shRNA (h) Lentiviral Particles - sc-42499-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

KCNE1 RNAi - H00003753-R01V from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human
Western Blot: KCNE1 RNAi [H00003753-R01V] - Analysis of KCNE1 over-expressed 293 cell line, cotransfected with KCNE1 Validated Chimera RNAi or or non-transfected control. Blot probed with H00003753-M01. GAPDH(36.1 kDa) used as loading control.

KCNE1 RNAi - H00003753-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

CompoZr® Knockout ZFN Kit - CKOZFN10932 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10932 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

KCNE1 siRNA (Human) - CRH2529 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

KCNE1, siRNA - MBS8230761 from MyBioSource

Category siRNA
Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human KCNE1 (NM_000219.4) - SHH322915 from Creative biogene

Category siRNA
Species Reactivities Human

Human KCNE1 siRNA - orb263031 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

KCNE1 shRNA Plasmid (Human) - CHH2529 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human
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