ABCA2
| Gene Symbol | ABCA2 |
|---|---|
| Entrez Gene | 20 |
| Alt Symbol | ABC2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | ATP-binding cassette, sub-family A (ABC1), member 2 |
| Other Description | ATP-binding cassette 2|ATP-binding cassette sub-family A member 2|ATP-binding cassette transporter 2|ATP-binding cassette, sub-family A, member 2 |
| Swissprots | Q76MW7 Q5W9G5 Q9HC28 A6NED5 Q9BZC7 Q5SPY5 |
| Accessions | AAK14335 EAW88331 EAW88332 EAW88333 Q9BZC7 AB028985 BAA83014 AB177854 BAD66832 AF178941 AAG09372 AF327657 AAK14334 AK295489 BAG58411 AK308738 AL162060 CAB82398 AL525193 AL833967 BC008755 AAH08755 BC029282 BC064542 AAH64542 BC090860 BC109244 AAI09245 BC144588 BC144589 BC172448 AAI72448 BE273611 BF516223 BF983101 BI195329 BM314339 BM474929 BM921242 BM921499 CD612070 CD676110 DB168116 JF279959 JF279960 U18235 AAA84436 U18236 AAA84437 XM_006716996 XP_006717059 XM_011518346 XP_011516648 NM_001606 NP_001597 NM_212533 NP_997698 |
| Function | Probable transporter, its natural substrate has not been found yet. May have a role in macrophage lipid metabolism and neural development. |
| Subcellular Location | Endosome membrane {ECO:0000269|PubMed:11309290}; Multi-pass membrane protein {ECO:0000269|PubMed:11309290}. Lysosome membrane {ECO:0000269|PubMed:11309290}; Multi-pass membrane protein {ECO:0000269|PubMed:11309290}. Note=Forms discrete, punctate intracellular vesicles. |
| Tissue Specificity | Highly expressed in the brain, whereas lower levels of expression is observed in kidney and liver. {ECO:0000269|PubMed:11309290}. |
| Top Pathways | ABC transporters, Lysosome |
ABCA2 CRISPR/Cas9 KO Plasmid (h) - sc-405934 from Santa Cruz Biotechnology
|
||||||||
ABCA2 HDR Plasmid (h) - sc-405934-HDR from Santa Cruz Biotechnology
|
||||||||
ABCA2 Double Nickase Plasmid (h) - sc-405934-NIC from Santa Cruz Biotechnology
|
||||||||
ABCA2 Double Nickase Plasmid (h2) - sc-405934-NIC-2 from Santa Cruz Biotechnology
|
||||||||
ABCA2 CRISPR Activation Plasmid (h) - sc-405934-ACT from Santa Cruz Biotechnology
|
||||||||
ABCA2 CRISPR Activation Plasmid (h2) - sc-405934-ACT-2 from Santa Cruz Biotechnology
|
||||||||
ABCA2 Lentiviral Activation Particles (h) - sc-405934-LAC from Santa Cruz Biotechnology
|
||||||||
ABCA2 Lentiviral Activation Particles (h2) - sc-405934-LAC-2 from Santa Cruz Biotechnology
|
||||||||
ABCA2 siRNA (h) - sc-60111 from Santa Cruz Biotechnology
|
||||||||
ABCA2 shRNA Plasmid (h) - sc-60111-SH from Santa Cruz Biotechnology
|
||||||||
ABCA2 shRNA (h) Lentiviral Particles - sc-60111-V from Santa Cruz Biotechnology
|
||||||||
ABCA2 RNAi - H00000020-R04 from Novus Biologicals
|
||||||||
MISSION® esiRNA - EHU157261 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit - CKOZFN2587 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2587 from Sigma-Aldrich
|
||||||||
MISSION® 3′UTR Lenti GoClone™ - HUTR06236 from Sigma-Aldrich
|
||||||||
ABCA2 siRNA (Human) - CRH0012 from Cohesion Biosciences
|
||||||||
ABCA2 RNAi - H00000020-R03 from Novus Biologicals
|
||||||||
ABCA2 - MBS8210257 from MyBioSource
|
||||||||
ABCA2 CRISPR/Cas9 KO Plasmid (h2) - sc-405934-KO-2 from Santa Cruz Biotechnology
|
||||||||
ABCA2 HDR Plasmid (h2) - sc-405934-HDR-2 from Santa Cruz Biotechnology
|
||||||||
shRNA set against Human ABCA2 (NM_001606.4) - SHH228838 from Creative biogene
|
||||||||
shRNA set against Human ABCA2(NM_212533.2) - SHG022753 from Creative biogene
|
||||||||
shRNA set against Human ABCA2(NM_001606.4) - SHG022763 from Creative biogene
|
||||||||
shRNA set against Human ABCA2(NM_212533.2) - SHG022777 from Creative biogene
|