Gene Symbol | PROZ |
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Entrez Gene | 8858 |
Alt Symbol | PZ |
Species | Human |
Gene Type | protein-coding |
Description | protein Z, vitamin K-dependent plasma glycoprotein |
Other Description | vitamin K-dependent protein Z |
Swissprots | Q5JVF6 P22891 Q5JVF5 A6NMB4 Q15213 |
Accessions | AAL27631 ACA06105 BAA85763 BAA85764 EAX09186 EAX09187 EAX09188 P22891 AI492996 BC074906 AAH74906 BC074907 AAH74907 M55670 AAA36500 M55671 AAA36501 M59303 AAA36499 XM_011537525 XP_011535827 NM_001256134 NP_001243063 NM_003891 NP_003882 |
Function | Appears to assist hemostasis by binding thrombin and promoting its association with phospholipid vesicles. Inhibits activity of the coagulation protease factor Xa in the presence of SERPINA10, calcium and phospholipids. |
Subcellular Location | Secreted. |
Tissue Specificity | Plasma. |
Protein Z CRISPR/Cas9 KO Plasmid (h) - sc-407610 from Santa Cruz Biotechnology
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Protein Z HDR Plasmid (h) - sc-407610-HDR from Santa Cruz Biotechnology
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Protein Z Double Nickase Plasmid (h) - sc-407610-NIC from Santa Cruz Biotechnology
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Protein Z Double Nickase Plasmid (h2) - sc-407610-NIC-2 from Santa Cruz Biotechnology
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Protein Z CRISPR Activation Plasmid (h) - sc-407610-ACT from Santa Cruz Biotechnology
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Protein Z CRISPR Activation Plasmid (h2) - sc-407610-ACT-2 from Santa Cruz Biotechnology
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Protein Z Lentiviral Activation Particles (h) - sc-407610-LAC from Santa Cruz Biotechnology
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Protein Z Lentiviral Activation Particles (h2) - sc-407610-LAC-2 from Santa Cruz Biotechnology
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Protein Z siRNA (h) - sc-106450 from Santa Cruz Biotechnology
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Protein Z shRNA Plasmid (h) - sc-106450-SH from Santa Cruz Biotechnology
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Protein Z shRNA (h) Lentiviral Particles - sc-106450-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU059831 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN17469 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17469 from Sigma-Aldrich
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PROZ siRNA (Human) - CRH5850 from Cohesion Biosciences
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Protein Z RNAi - H00008858-R01 from Novus Biologicals
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shRNA set against Human PROZ (NM_003891.2) - SHH383664 from Creative biogene
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PROZ shRNA Plasmid (Human) - CHH5850 from Cohesion Biosciences
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PROZ miRNA 3'UTR clone - MiUTR3H-01905 from Creative biogene
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