Fen1

Gene Symbol Fen1
Entrez Gene 36887
Alt Symbol CG8648, DmFEN-1, Dmel\CG8648, EG:EG0003.3, FEN1, fen1
Species Drosophila
Gene Type protein-coding
Description Flap endonuclease 1
Other Description CG8648-PA|Fen1-PA|flap endonuclease 1|flap endonuclease-1
Swissprots Q7K7A9
Accessions AAF57944 CAA21320 O96830 Q7K7A9 BT100031 ACX54939 NM_079041 NP_523765
Function Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double- stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA. {ECO:0000255|HAMAP-Rule:MF_03140}.
Subcellular Location Nucleus, nucleolus {ECO:0000255|HAMAP- Rule:MF_03140}. Nucleus, nucleoplasm {ECO:0000255|HAMAP- Rule:MF_03140}. Mitochondrion {ECO:0000255|HAMAP-Rule:MF_03140}. Note=Resides mostly in the nucleoli and relocalizes to the nucleoplasm upon DNA damage. {ECO:0000255|HAMAP-Rule:MF_03140}.
Top Pathways DNA replication, Base excision repair, Non-homologous end-joining

Recombinant Drosophila melanogaster Flap endonuclease 1(Fen1) - CSB-YP741960DLU CSB-EP741960DLU CSB-BP741960DLU CSB-MP741960DLU from Cusabio

Category Protein
Source Yeast or E.coli or Baculovirus or Mammalian cell
Species Drosophila

Flap endonuclease 1 (Fen1), Recombinant Protein - MBS1110073 from MyBioSource

Category Protein
Prices $1,155.00, $1,155.00, $1,385.00, $1,385.00, $1,845.00, $1,845.00, $2,310.00, $2,310.00
Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell)
Source E Coli or Yeast or Baculovirus or Mammalian Cell
Species Drosophila

Flap endonuclease 1 (Fen1), Recombinant Protein - MBS1193542 from MyBioSource

Category Protein
Prices $1,155.00, $1,155.00, $1,385.00, $1,385.00, $1,845.00, $1,845.00, $2,310.00, $2,310.00
Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell)
Source E Coli or Yeast or Baculovirus or Mammalian Cell
Species Drosophila

Flap endonuclease 1 (Fen1), Recombinant Protein - MBS1033548 from MyBioSource

Category Protein
Prices $1,160.00, $1,160.00, $1,390.00, $1,390.00, $1,855.00, $1,855.00, $2,315.00, $2,315.00
Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell)
Source E Coli or Yeast or Baculovirus or Mammalian Cell
Species Drosophila

Flap endonuclease 1 (Fen1), Recombinant Protein - MBS1386844 from MyBioSource

Category Protein
Prices $1,155.00, $1,155.00, $1,385.00, $1,385.00, $1,845.00, $1,845.00, $2,310.00, $2,310.00
Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell)
Source E Coli or Yeast or Baculovirus or Mammalian Cell
Species Drosophila

Flap endonuclease 1 (Fen1), Recombinant Protein - MBS1192041 from MyBioSource

Category Protein
Prices $1,155.00, $1,155.00, $1,385.00, $1,385.00, $1,845.00, $1,845.00, $2,310.00, $2,310.00
Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell)
Source E Coli or Yeast or Baculovirus or Mammalian Cell
Species Drosophila

Flap endonuclease 1 (Fen1), Recombinant Protein - MBS1206125 from MyBioSource

Category Protein
Prices $1,160.00, $1,160.00, $1,390.00, $1,390.00, $1,855.00, $1,855.00, $2,315.00, $2,315.00
Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell)
Source E Coli or Yeast or Baculovirus or Mammalian Cell
Species Drosophila

Flap endonuclease 1 (Fen1), Recombinant Protein - MBS1144180 from MyBioSource

Category Protein
Prices $1,155.00, $1,155.00, $1,385.00, $1,385.00, $1,845.00, $1,845.00, $2,310.00, $2,310.00
Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell)
Source E Coli or Yeast or Baculovirus or Mammalian Cell
Species Drosophila

Flap endonuclease 1 (Fen1), Recombinant Protein - MBS1105268 from MyBioSource

Category Protein
Prices $1,160.00, $1,160.00, $1,390.00, $1,390.00, $1,855.00, $1,855.00, $2,315.00, $2,315.00
Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell)
Source E Coli or Yeast or Baculovirus or Mammalian Cell
Species Drosophila

Flap endonuclease 1 (Fen1), Recombinant Protein - MBS1181046 from MyBioSource

Category Protein
Prices $1,160.00, $1,160.00, $1,390.00, $1,390.00, $1,855.00, $1,855.00, $2,315.00, $2,315.00
Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell)
Source E Coli or Yeast or Baculovirus or Mammalian Cell
Species Drosophila

Flap endonuclease 1 (Fen1), Recombinant Protein - MBS1070541 from MyBioSource

Category Protein
Prices $1,155.00, $1,155.00, $1,385.00, $1,385.00, $1,845.00, $1,845.00, $2,310.00, $2,310.00
Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell)
Source E Coli or Yeast or Baculovirus or Mammalian Cell
Species Drosophila

Flap endonuclease 1 (Fen1), Recombinant Protein - MBS1155040 from MyBioSource

Category Protein
Prices $1,155.00, $1,155.00, $1,385.00, $1,385.00, $1,850.00, $1,850.00, $2,315.00, $2,315.00
Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell)
Source E Coli or Yeast or Baculovirus or Mammalian Cell
Species Drosophila

Flap endonuclease 1 (Fen1), Recombinant Protein - MBS1060605 from MyBioSource

Category Protein
Prices $1,155.00, $1,155.00, $1,385.00, $1,385.00, $1,850.00, $1,850.00, $2,315.00, $2,315.00
Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell)
Source E Coli or Yeast or Baculovirus or Mammalian Cell
Species Drosophila
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