Gene Symbol | PARP16 |
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Entrez Gene | 54956 |
Alt Symbol | ARTD15, C15orf30, pART15 |
Species | Human |
Gene Type | protein-coding |
Description | poly (ADP-ribose) polymerase family, member 16 |
Other Description | ADP-ribosyltransferase diphtheria toxin-like 15|PARP-16|mono [ADP-ribose] polymerase PARP16|poly [ADP-ribose] polymerase 16 |
Swissprots | Q8N5Y8 Q9NX03 Q6PK64 |
Accessions | EAW77718 EAW77719 EAW77720 EAW77721 Q8N5Y8 AK000516 BAA91222 AK058010 BC006389 AAH06389 BC031074 AAH31074 JF432500 ADZ15717 XM_005254516 XP_005254573 XM_006720589 XP_006720652 XM_006720590 XP_006720653 XM_006720592 XP_006720655 XM_011521742 XP_011520044 XR_429459 XR_429460 NM_017851 NP_060321 |
Function | Intracellular mono-ADP-ribosyltransferase that may play a role in different processes through the mono-ADP-ribosylation of proteins involved in those processes (PubMed:23103912, PubMed:22701565). May play a role in the unfolded protein response (UPR), by ADP-ribosylating and activating EIF2AK3 and ERN1, two important UPR effectors (PubMed:23103912). May also mediate mono- ADP-ribosylation of karyopherin KPNB1 a nuclear import factor (PubMed:22701565). May not modify proteins on arginine, cysteine or glutamate residues compared to other mono-ADP- ribosyltransferases (PubMed:22701565). {ECO:0000269|PubMed:22701565, ECO:0000269|PubMed:23103912}. |
Subcellular Location | Endoplasmic reticulum membrane; Single-pass type IV membrane protein {ECO:0000269|PubMed:22701565}. |
PARP-16 CRISPR/Cas9 KO Plasmid (h) - sc-408242 from Santa Cruz Biotechnology
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PARP-16 HDR Plasmid (h) - sc-408242-HDR from Santa Cruz Biotechnology
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PARP-16 Double Nickase Plasmid (h) - sc-408242-NIC from Santa Cruz Biotechnology
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PARP-16 Double Nickase Plasmid (h2) - sc-408242-NIC-2 from Santa Cruz Biotechnology
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PARP-16 CRISPR Activation Plasmid (h) - sc-408242-ACT from Santa Cruz Biotechnology
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PARP-16 CRISPR Activation Plasmid (h2) - sc-408242-ACT-2 from Santa Cruz Biotechnology
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PARP-16 Lentiviral Activation Particles (h) - sc-408242-LAC from Santa Cruz Biotechnology
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PARP-16 Lentiviral Activation Particles (h2) - sc-408242-LAC-2 from Santa Cruz Biotechnology
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PARP-16 siRNA (h) - sc-76060 from Santa Cruz Biotechnology
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PARP-16 shRNA Plasmid (h) - sc-76060-SH from Santa Cruz Biotechnology
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PARP-16 shRNA (h) Lentiviral Particles - sc-76060-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU064651 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN16347 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND16347 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR08802 from Sigma-Aldrich
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PARP16 siRNA (Human) - CRJ0356 from Cohesion Biosciences
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shRNA set against Human PARP16 (NM_017851.4) - SHH370872 from Creative biogene
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shRNA set against Human PARP16(NM_017851.4) - SHR088598 from Creative biogene
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PARP16 shRNA Plasmid (Human) - CHJ0356 from Cohesion Biosciences
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PARP16 miRNA 3'UTR clone - MiUTR1H-07522 from Creative biogene
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