Foxo1

Gene Symbol	Foxo1
Entrez Gene	56458
Alt Symbol	AI876417, Afxh, FKHR, Fkhr1, Foxo1a
Species	Mouse
Gene Type	protein-coding
Description	forkhead box O1
Other Description	forkhead box O1a|forkhead box protein O1|forkhead box protein O1A|forkhead in rhabdomyosarcoma|forkhead protein 1
Swissprots	Q9R1E0 Q9JJW4
Accessions	EDL35224 Q9R1E0 AF114258 AAD42106 AF126056 AAD40636 AJ252157 CAB86873 AK029013 AK030304 AK039265 BAC30298 AK043583 BAC31588 AK053633 BAC35455 AK054289 AK137629 BAE23437 AK154041 BAE32333 AK185432 AK192846 AK211466 AK211487 AK212278 AK212379 BC152908 AAI52909 NM_019739 NP_062713
Function	Transcription factor that is the main target of insulin signaling and regulates metabolic homeostasis in response to oxidative stress. Binds to the insulin response element (IRE) with consensus sequence 5'-TT[G/A]TTTTG-3' and the related Daf-16 family binding element (DBE) with consensus sequence 5'- TT[G/A]TTTAC-3'. Activity suppressed by insulin. Main regulator of redox balance and osteoblast numbers and controls bone mass. Orchestrates the endocrine function of the skeleton in regulating glucose metabolism. Acts synergistically with ATF4 to suppress osteocalcin/BGLAP activity, increasing glucose levels and triggering glucose intolerance and insulin insensitivity. Also suppresses the transcriptional activity of RUNX2, an upstream activator of osteocalcin/BGLAP. In hepatocytes, promotes gluconeogenesis by acting together with PPARGC1A and CEBPA to activate the expression of genes such as IGFBP1, G6PC and PCK1. Important regulator of cell death acting downstream of CDK1, PKB/AKT1 and S
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:21317886}. Nucleus {ECO:0000269|PubMed:17627282, ECO:0000269|PubMed:21317886}. Note=Shuttles between the cytoplasm and nucleus. Largely nuclear in unstimulated cells. In osteoblasts, colocalizes with ATF4 and RUNX2 in the nucleus (By similarity). Insulin-induced phosphorylation at Ser-253 by PKB/AKT1 leads, via stimulation of Thr-24 phosphorylation, to binding of 14-3-3 proteins and nuclear export to the cytoplasm where it is degraded by the ubiquitin-proteosomal pathway. Phosphorylation at Ser-249 by CDK1 disrupts binding of 14-3-3 proteins and promotes nuclear accumulation. Phosphorylation by NLK results in nuclear export. Translocates to the nucleus upon oxidative stress-induced phosphorylation at Ser-212 by STK4/MST1. SGK1-mediated phosphorylation also results in nuclear translocation. Retained in the nucleus under stress stimuli including oxidative stress, nutrient deprivation or nitric oxide. Methylated form is nuclear. {ECO:0000250}.
Tissue Specificity	Expressed in liver, white and brown adipose tissues (at protein level). {ECO:0000269|PubMed:17627282, ECO:0000269|PubMed:22510882}.
Top Pathways	Insulin signaling pathway, Prostate cancer, AMPK signaling pathway, Glucagon signaling pathway, Transcriptional misregulation in cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SignalSilence ® FoxO1 siRNA I (Mouse Specific) - 6468 from Cell Signaling Technology Category siRNA Prices $256.00 Sizes 300 µl (3 nmol) Species Reactivities Mouse

SignalSilence ® FoxO1 siRNA II (Mouse Specific) - 6493 from Cell Signaling Technology Category siRNA Prices $256.00 Sizes 300 µl (3 nmol) Species Reactivities Mouse

FKHR CRISPR/Cas9 KO Plasmid (m) - sc-425179 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Mouse

FKHR HDR Plasmid (m) - sc-425179-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Mouse

FKHR Double Nickase Plasmid (m) - sc-425179-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Mouse

FKHR Double Nickase Plasmid (m2) - sc-425179-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Mouse

FKHR CRISPR Activation Plasmid (m) - sc-425179-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Mouse

FKHR CRISPR Activation Plasmid (m2) - sc-425179-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Mouse

FKHR Lentiviral Activation Particles (m) - sc-425179-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Mouse

FKHR Lentiviral Activation Particles (m2) - sc-425179-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Mouse

FKHR siRNA (m) - sc-35383 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Mouse

FKHR shRNA Plasmid (m) - sc-35383-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Mouse

FKHR shRNA (m) Lentiviral Particles - sc-35383-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Mouse

CompoZr® Knockout ZFN Kit - CKOZFN31520 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND31520 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

FOXO1 siRNA (Mouse) - CRM5814 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Mouse

FOXO1 - MBS8215827 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Mouse

shRNA set against Mouse FOXO1 (NM_019739.3) - SHH296757 from Creative biogene Category siRNA Species Reactivities Mouse

Mouse FOXO1 siRNA - orb285290 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Mouse

FOXO1 shRNA Plasmid (Mouse) - CHM5814 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Mouse

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