POLR1A

Gene Symbol POLR1A
Entrez Gene 25885
Alt Symbol A190, RPA1, RPA194, RPO1-4, RPO14
Species Human
Gene Type protein-coding
Description polymerase (RNA) I polypeptide A, 194kDa
Other Description DNA-directed RNA polymerase I largest subunit|DNA-directed RNA polymerase I subunit A|DNA-directed RNA polymerase I subunit A1|DNA-directed RNA polymerase I subunit RPA1|RNA polymerase I 194 kDa subunit|RNA polymerase I subunit A1
Swissprots Q0VG05 Q9UFT9 B7Z7T0 O95602 D6W5M0 Q9UEH0
Accessions AAY24277 EAW99467 EAW99468 EAW99469 O95602 AK025568 BAB15171 AK294447 BAH11770 AK302458 BAH13716 AK304131 BAH14113 AK307490 AL117467 CAB55942 BC017115 AAH17115 BC073968 BC117173 AAI17174 BC126303 AAI26304 BC143345 AAI43346 BP363163 U33460 AAC99959 XM_006711983 XP_006712046 NM_015425 NP_056240
Function DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Forms the polymerase active center together with the second largest subunit. A single stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol I. A bridging helix emanates from RPA1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol I by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition (By similarity). {ECO:0000250}.
Subcellular Location Nucleus, nucleolus {ECO:0000250}.
Top Pathways Purine metabolism, RNA polymerase, Pyrimidine metabolism

RPA194 (C-1) - sc-48385 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
RPA194 (C-1): sc-48385. Immunoperoxidase staining of formalin fixed, paraffin-embedded human tonsil tissue showing nuclear staining of surface epthelial and non-follicle cells at low (A) and high (B) magnification. Kindly provided by The Swedish Human Protein Atlas (HPA) program.

RPA194 (D-20) - sc-32102 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

RPA194 (F-6) - sc-46699 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
RPA194 (F-6): sc-46699. Western blot analysis of RPA194 expression in RAW 264.7 (A) and KNRK (B) nuclear extracts.

RPA194 (H-300) - sc-28714 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
RPA194 (H-300): sc-28714. Western blot analysis of RPA194 expression in KNRK (A) and HeLa (B) nuclear extracts. Note presence of proteolytically cleaved forms.

RPA194 (N-16) - sc-17916 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
RPA194 (N-16): sc-17916. Western blot analysis of RPA194 expression in RAW 264.7 nuclear extract.

Anti-POLR1A antibody - ab192389 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-POLR1A antibody (ab192389)Lane 1 : HEK293T whole cell lysateLane 2 : NIH-3T3 whole cell lysateLane 3 : H9C2 whole cell lysate

Anti-POLR1A antibody - C-terminal - ab139130 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-POLR1A antibody - C-terminal (ab139130) at 1/100 dilution + A375 cell line lysates at 35 µgdeveloped using the ECL technique

Anti-POLR1A Antibody (aa1437-1465, AP) - LS-C239277 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-POLR1A Antibody (aa1437-1465, APC) - LS-C239278 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-POLR1A Antibody (aa1437-1465, FITC) - LS-C239280 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-POLR1A Antibody (aa1437-1465, Biotin) - LS-C239279 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-POLR1A Antibody (aa1437-1465, PE) - LS-C239282 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-POLR1A Antibody (aa1437-1465, Azide-free, HRP) - LS-C248518 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-POLR1A Antibody (aa1437-1465) - LS-C324164 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-POLR1A Antibody - LS-C340969 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-POLR1A Antibody (aa1437-1465) - LS-C158696 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
POLR1A Antibody western blot of A375 cell line lysates (35 ug/lane). The POLR1A antibody detected the POLR1A protein (arrow).

POLR1A Antibody - NBP2-32016 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry: POLR1A Antibody [NBP2-32016] - Staining of human cerebral cortex shows strong nuclear positivity in neuronal cells and glial cells.

ANTI-POLR1A(C-TERMINAL) antibody produced in rabbit - SAB1305857 from Sigma-Aldrich

Prices $326.00
Sizes 40 tst
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-POLR1A (C-term): <B>Cat. No. SAB1305857</B>: POLR1A Antibody (C-term) western blot analysis in A375 cell line lysates (35 μg/lane).

Anti-POLR1A antibody produced in rabbit - HPA031513 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-POLR1A: <B>Cat. No. HPA031513</B>: Immunohistochemical staining of Human cerebral cortex shows strong nuclear positivity in neuronal cells and glial cells.

POLR1A-Antibody-C-term - AP18976b from Abgent, a WuXi AppTec company

Prices $99.00, $295.00
Sizes 80 µl, 400 µl
Host Rabbit
Clonality Polyclonal
POLR1A Antibody (C-term) (Cat. #AP18976b) western blot analysis in A375 cell line lysates (35ug/lane).This demonstrates the POLR1A antibody detected the POLR1A protein (arrow).

POLR1A Antibody - C-terminal region (OAAB14514) - OAAB14514 from Aviva Systems Biology

Prices $289.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal

RPA1 antibody - 70R-19947 from Fitzgerald

Prices $375.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal

RPA1 antibody - 70R-5545 from Fitzgerald

Prices $345.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

RPA1 antibody - orb32563 from Biorbyt

Prices $187.00, $383.00
Sizes 80 μl (Trial size), 400 μl
Host Rabbit
Clonality Polyclonal

RPA70 antibody - 70R-13226 from Fitzgerald

Prices $395.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
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