ASIC3
| Gene Symbol | ASIC3 |
|---|---|
| Entrez Gene | 9311 |
| Alt Symbol | ACCN3, DRASIC, SLNAC1, TNaC1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | acid sensing (proton gated) ion channel 3 |
| Other Description | acid-sensing (proton-gated) ion channel 3|acid-sensing ion channel 3|amiloride-sensitive cation channel 3, testis|modulatory subunit of ASIC2a|neuronal amiloride-sensitive cation channel 3|proton-gated cation channel subunit|testis sodium channel 1 |
| Swissprots | Q9UHC4 B2R9V0 O60263 Q9UER8 O75906 Q9UHC3 Q59FN9 |
| Accessions | CAB69243 CAB69244 CAB69252 EAL24495 EAL24496 EAL24497 EAW54052 EAW54053 EAW54054 EAW54055 Q9UHC3 AB010575 BAA25897 AB209421 BAD92658 AF057711 AAC62935 AF095897 AAC64188 AF195024 AAF19817 AF195025 AAF19818 AI580095 AK128129 AK313926 BAG36647 BC030282 BC156796 AAI56797 NM_004769 NP_004760 NM_020321 NP_064717 NM_020322 NP_064718 NR_046401 |
| Function | Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Generates a biphasic current with a fast inactivating and a slow sustained phase. In sensory neurons is proposed to mediate the pain induced by acidosis that occurs in ischemic, damaged or inflamed tissue. May be involved in hyperalgesia. May play a role in mechanoreception. Heteromeric channel assembly seems to modulate channel properties. {ECO:0000269|PubMed:9744806, ECO:0000269|PubMed:9886053}. |
| Subcellular Location | Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Cell surface expression may be stabilized by interaction with LIN7B and cytoplasmic retention by interaction with DLG4. In part cytoplasmic in cochlea cells (By similarity). {ECO:0000250}. |
| Tissue Specificity | Expressed by sensory neurons. Strongly expressed in brain, spinal chord, lung, lymph nodes, kidney, pituitary, heart and testis. {ECO:0000269|PubMed:9571199, ECO:0000269|PubMed:9886053}. |
| Top Pathways | Inflammatory mediator regulation of TRP channels |
ASIC3 CRISPR/Cas9 KO Plasmid (h) - sc-405106 from Santa Cruz Biotechnology
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ASIC3 HDR Plasmid (h) - sc-405106-HDR from Santa Cruz Biotechnology
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ASIC3 Double Nickase Plasmid (h) - sc-405106-NIC from Santa Cruz Biotechnology
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ASIC3 Double Nickase Plasmid (h2) - sc-405106-NIC-2 from Santa Cruz Biotechnology
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ASIC3 CRISPR Activation Plasmid (h) - sc-405106-ACT from Santa Cruz Biotechnology
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ASIC3 CRISPR Activation Plasmid (h2) - sc-405106-ACT-2 from Santa Cruz Biotechnology
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ASIC3 Lentiviral Activation Particles (h) - sc-405106-LAC from Santa Cruz Biotechnology
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ASIC3 Lentiviral Activation Particles (h2) - sc-405106-LAC-2 from Santa Cruz Biotechnology
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ASIC3 siRNA (h) - sc-105101 from Santa Cruz Biotechnology
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ASIC3 shRNA Plasmid (h) - sc-105101-SH from Santa Cruz Biotechnology
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ASIC3 shRNA (h) Lentiviral Particles - sc-105101-V from Santa Cruz Biotechnology
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Amiloride-sensitive cation channel 3 RNAi - H00009311-R02 from Novus Biologicals
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CompoZr® Knockout ZFN Kit - CKOZFN2709 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2709 from Sigma-Aldrich
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ASIC3 siRNA (Human) - CRH6158 from Cohesion Biosciences
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Amiloride-sensitive cation channel 3 RNAi - H00009311-R03 from Novus Biologicals
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Amiloride-sensitive cation channel 3 RNAi - H00009311-R01 from Novus Biologicals
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ASIC3 - MBS8207016 from MyBioSource
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shRNA set against Human ACCN3 (NM_004769.3) - SHH230134 from Creative biogene
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ASIC3 shRNA Plasmid (Human) - CHH6158 from Cohesion Biosciences
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ASIC3 miRNA 3'UTR clone - MiUTR3H-12073 from Creative biogene
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ASIC3 miRNA 3'UTR clone - MiUTR3H-12074 from Creative biogene
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