| Gene Symbol | APOE |
|---|---|
| Entrez Gene | 348 |
| Alt Symbol | AD2, APO-E, LDLCQ5, LPG |
| Species | Human |
| Gene Type | protein-coding |
| Description | apolipoprotein E |
| Other Description | apolipoprotein E3 |
| Swissprots | Q9P2S4 P02649 C0JYY5 B2RC15 |
| Accessions | AAB59397 AAD02505 AAG27089 AAL82810 ACN81314 ADK26133 AFS60672 BAA96080 CAA63051 EAW57306 P02649 AK308546 AK314898 BAG37412 AL037046 BC003557 AAH03557 BI550631 BM042032 BU848796 CA771535 DB486513 DQ892548 ABM83474 DQ895759 ABM86685 HY056112 HY074384 HY074888 K00396 AAB59546 M12529 AAB59518 X00199 CAA25017 Z70760 CAA94806 NM_000041 NP_000032 NM_001302688 NP_001289617 NM_001302689 NP_001289618 NM_001302690 NP_001289619 NM_001302691 NP_001289620 |
| Function | Mediates the binding, internalization, and catabolism of lipoprotein particles. It can serve as a ligand for the LDL (apo B/E) receptor and for the specific apo-E receptor (chylomicron remnant) of hepatic tissues. |
| Subcellular Location | Secreted. |
| Tissue Specificity | Occurs in all lipoprotein fractions in plasma. It constitutes 10-20% of very low density lipoproteins (VLDL) and 1-2% of high density lipoproteins (HDL). APOE is produced in most organs. Significant quantities are produced in liver, brain, spleen, lung, adrenal, ovary, kidney and muscle. |
| Top Pathways | Alzheimer's disease |