| Gene Symbol | Plcb1 |
|---|---|
| Entrez Gene | 24654 |
| Alt Symbol | PLC'1, PLCbeta1, Phosphb, RATPHOSPHB |
| Species | Rat |
| Gene Type | protein-coding |
| Description | phospholipase C, beta 1 (phosphoinositide-specific) |
| Other Description | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1|1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-1|PLC-154|PLC-I|PLC-beta-1|Phospholipase C-beta1|phosphoinositide phospholipase C|phosphoinositide phospholipase C-beta-1|phospholipase C-I|phospholipase C-beta-1 |
| Swissprots | P10687 |
| Accessions | EDL80287 P10687 L14323 M20636 AAA41885 XM_008762247 XP_008760469 NM_001077641 NP_001071109 |
| Function | The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. |
| Subcellular Location | Nucleus membrane {ECO:0000250}. Cytoplasm {ECO:0000269|PubMed:8454637}. Note=Colocalizes with the adrenergic receptors, ADREN1A and ADREN1B, at the nuclear membrane of cardiac myocytes. {ECO:0000250}. |
| Tissue Specificity | Highest expression in brain. Also expressed in parotid gland, liver, uterus, lung, heart, adrenal gland and ovary. Not detected in spleen, pancreas, intestine, thymus or kidney. {ECO:0000269|PubMed:8454637}. |
| Top Pathways | Oxytocin signaling pathway, cGMP-PKG signaling pathway, Thyroid hormone synthesis, Adrenergic signaling in cardiomyocytes, Inflammatory mediator regulation of TRP channels |