| Gene Symbol |
Plcb1
|
| Entrez Gene |
24654
|
| Alt Symbol |
PLC'1, PLCbeta1, Phosphb, RATPHOSPHB
|
| Species |
Rat
|
| Gene Type |
protein-coding
|
| Description |
phospholipase C, beta 1 (phosphoinositide-specific)
|
| Other Description |
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1|1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-1|PLC-154|PLC-I|PLC-beta-1|Phospholipase C-beta1|phosphoinositide phospholipase C|phosphoinositide phospholipase C-beta-1|phospholipase C-I|phospholipase C-beta-1
|
| Swissprots |
P10687
|
| Accessions |
EDL80287 P10687 L14323 M20636 AAA41885 XM_008762247 XP_008760469 NM_001077641 NP_001071109
|
| Function |
The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.
|
| Subcellular Location |
Nucleus membrane {ECO:0000250}. Cytoplasm {ECO:0000269|PubMed:8454637}. Note=Colocalizes with the adrenergic receptors, ADREN1A and ADREN1B, at the nuclear membrane of cardiac myocytes. {ECO:0000250}.
|
| Tissue Specificity |
Highest expression in brain. Also expressed in parotid gland, liver, uterus, lung, heart, adrenal gland and ovary. Not detected in spleen, pancreas, intestine, thymus or kidney. {ECO:0000269|PubMed:8454637}.
|
| Top Pathways |
Oxytocin signaling pathway, cGMP-PKG signaling pathway, Thyroid hormone synthesis, Adrenergic signaling in cardiomyocytes, Inflammatory mediator regulation of TRP channels
|