| Gene Symbol |
MCM9
|
| Entrez Gene |
254394
|
| Alt Symbol |
C6orf61, MCMDC1, ODG4, dJ329L24.1, dJ329L24.3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
minichromosome maintenance complex component 9
|
| Other Description |
DNA helicase MCM9|DNA replication licensing factor MCM9|mini-chromosome maintenance deficient domain-containing protein 1
|
| Swissprots |
Q8N5S5 B9DI77 Q9NXL9 Q9HCV5 Q2KHJ0 B4DR30
|
| Accessions |
EAW48191 EAW48192 Q9NXL9 AK000177 BAA90991 AK122665 BAG53653 AK225233 AK299076 BAG61142 BC024976 BC031658 AAH31658 BN000882 CAJ70648 BX649114 DB453085 DB476942 DQ892465 ABM83391 DQ895678 ABM86604 NM_017696 NP_060166 NM_153255 NP_694987
|
| Function |
Component of the MCM8-MCM9 complex, a complex involved in homologous recombination repair following DNA interstrand cross-links and plays a key role during gametogenesis. The MCM8- MCM9 complex probably acts as a hexameric helicase downstream of the Fanconi anemia proteins BRCA2 and RAD51 and is required to process aberrant forks into homologous recombination substrates and to orchestrate homologous recombination with resection, fork stabilization and fork restart. {ECO:0000269|PubMed:22771115}.
|
| Subcellular Location |
Nucleus {ECO:0000250}. Note=Localizes to nuclear foci and colocalizes with RAD51. {ECO:0000250}.
|
![Western Blot: MCM9 Overexpression Lysate (Adult Normal) [NBP2-05281] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for MCM9.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/6419_MCM9%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-05281-img0001.jpg)