| Gene Symbol |
CXCL16
|
| Entrez Gene |
58191
|
| Alt Symbol |
CXCLG16, SR-PSOX, SRPSOX
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
chemokine (C-X-C motif) ligand 16
|
| Other Description |
C-X-C motif chemokine 16|CXC chemokine ligand 16|scavenger receptor for phosphatidylserine and oxidized low density lipoprotein|small-inducible cytokine B16|transmembrane chemokine CXCL16
|
| Swissprots |
Q9H2F6 A0N0N4 Q8TC80 A8K7U9 Q9BXD6 B2RCB0 Q96K63 Q9H2A7
|
| Accessions |
ABK41925 EAW90416 Q9H2A7 AF275260 AAG31750 AF301016 AAG34365 AF337812 AAK38275 AK027389 BAB55078 AK292114 BAF84803 AK315017 BAG37507 AW264069 AY358909 AAQ89268 BC017588 AAH17588 BC044930 AAH44930 CA307348 DC373874 HQ448003 ADQ32484 JC209418 CDM22050 JC209420 CDM22051 NM_001100812 NP_001094282 NM_022059 NP_071342
|
| Function |
Acts as a scavenger receptor on macrophages, which specifically binds to OxLDL (oxidized low density lipoprotein), suggesting that it may be involved in pathophysiology such as atherogenesis (By similarity). Induces a strong chemotactic response. Induces calcium mobilization. Binds to CXCR6/Bonzo. {ECO:0000250}.
|
| Subcellular Location |
Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Secreted. Note=Also exists as a soluble form.
|
| Tissue Specificity |
Expressed in T-cell areas. Expressed in spleen, lymph nodes, lung, kidney, small intestine and thymus. Weak expression in heart and liver and no expression in brain and bone marrow.
|
| Top Pathways |
Cytokine-cytokine receptor interaction, Chemokine signaling pathway
|