| Gene Symbol |
Lpin2
|
| Entrez Gene |
64898
|
| Alt Symbol |
2610511G02Rik, AI481352, AW742896
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
lipin 2
|
| Other Description |
lipin-2|phosphatidate phosphatase LPIN2
|
| Swissprots |
Q8CC85 Q8C357 Q8C7I8 Q8CHR7 Q99PI5
|
| Accessions |
EDL38374 EDL38375 EDL38376 EDL38377 Q99PI5 AF286723 AAG52761 AK012110 AK021389 AK033662 BAC28415 AK033959 AK048657 AK050018 AK050138 BAC34088 AK085538 AK086834 BAC39754 AK136472 BAE22992 AK165218 AK165715 AK220156 BAD90342 AW489885 BC022663 BC039698 AAH39698 BC049811 XM_006524786 XP_006524849 XM_006524787 XP_006524850 XM_006524788 XP_006524851 XM_011246568 XP_011244870 NM_001164885 NP_001158357 NM_022882 NP_075020
|
| Function |
Plays important roles in controlling the metabolism of fatty acids at differents levels. Acts as a magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis in the reticulum endoplasmic membrane. Acts also as a nuclear transcriptional coactivator for PPARGC1A to modulate lipid metabolism. {ECO:0000269|PubMed:19136718, ECO:0000269|PubMed:19717560}.
|
| Subcellular Location |
Nucleus. Cytoplasm, cytosol. Endoplasmic reticulum membrane. Note=Translocates from cytosol to endoplasmic reticulum membrane with increasing levels of oleate.
|
| Tissue Specificity |
Expressed at high level in liver and to some extend in lung, kidney, placenta, spleen, thymus, lymph node, prostate, testes, small intestine, and colon. Expressed also in circulating red blood cells and site of lymphopoiesis. {ECO:0000269|PubMed:17158099, ECO:0000269|PubMed:19717560}.
|
| Top Pathways |
Glycerolipid metabolism, Glycerophospholipid metabolism
|