POLR2F
| Gene Symbol | POLR2F |
|---|---|
| Entrez Gene | 5435 |
| Alt Symbol | HRBP14.4, POLRF, RPABC14.4, RPABC2, RPB14.4, RPB6, RPC15 |
| Species | Human |
| Gene Type | protein-coding |
| Description | polymerase (RNA) II (DNA directed) polypeptide F |
| Other Description | DNA-directed RNA polymerase II subunit F|DNA-directed RNA polymerases I, II, and III 14.4 kDa polypeptide|DNA-directed RNA polymerases I, II, and III subunit RPABC2|RNA Polymerase II subunit 14.4 kD|RNA polymerases I, II, and III subunit ABC2 |
| Swissprots | P41584 Q6IAY3 P61218 |
| Accessions | CAA81629 EAW60202 EAW60203 P61218 AK026327 AK094034 AK098727 BAC05392 AK311128 AK311831 BAG34773 AL832562 BC003582 AAH03582 BP195499 BU160667 BU634038 CA396447 CR456546 CAG30432 CR457021 CAG33302 CU013146 CAK54577 CU013434 CAK54876 DA083933 DA203006 DA372532 DN989996 XM_011530235 XP_011528537 NM_001301129 NP_001288058 NM_001301130 NP_001288059 NM_001301131 NP_001288060 NM_021974 NP_068809 NR_125371 |
| Function | DNA-dependent RNA polymerases catalyze the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II, and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, POLR2F/RPB6 is part of the clamp element and together with parts of RPB1 and RPB2 forms a pocket to which the RPB4-RPB7 subcomplex binds (By similarity). {ECO:0000250}. |
| Subcellular Location | Nucleus {ECO:0000269|PubMed:9852112}. |
| Top Pathways | Huntington's disease, Cytosolic DNA-sensing pathway, Epstein-Barr virus infection, Purine metabolism, RNA polymerase |
Pol II RPB6 CRISPR/Cas9 KO Plasmid (h) - sc-406479 from Santa Cruz Biotechnology
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Pol II RPB6 HDR Plasmid (h) - sc-406479-HDR from Santa Cruz Biotechnology
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Pol II RPB6 Double Nickase Plasmid (h) - sc-406479-NIC from Santa Cruz Biotechnology
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Pol II RPB6 Double Nickase Plasmid (h2) - sc-406479-NIC-2 from Santa Cruz Biotechnology
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Pol II RPB6 CRISPR Activation Plasmid (h) - sc-406479-ACT from Santa Cruz Biotechnology
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Pol II RPB6 CRISPR Activation Plasmid (h2) - sc-406479-ACT-2 from Santa Cruz Biotechnology
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Pol II RPB6 Lentiviral Activation Particles (h) - sc-406479-LAC from Santa Cruz Biotechnology
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Pol II RPB6 Lentiviral Activation Particles (h2) - sc-406479-LAC-2 from Santa Cruz Biotechnology
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Pol I/II/III RPB6 siRNA (h) - sc-45868 from Santa Cruz Biotechnology
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Pol I/II/III RPB6 shRNA Plasmid (h) - sc-45868-SH from Santa Cruz Biotechnology
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Pol I/II/III RPB6 shRNA (h) Lentiviral Particles - sc-45868-V from Santa Cruz Biotechnology
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POLR2F RNAi - H00005435-R01 from Novus Biologicals
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MISSION® esiRNA - EHU056921 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN17116 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17116 from Sigma-Aldrich
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POLR2F siRNA (Human) - CRH3638 from Cohesion Biosciences
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shRNA set against Human POLR2F (NM_021974.3) - SHH379436 from Creative biogene
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Human POLR2F siRNA - orb264140 from Biorbyt
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POLR2F shRNA Plasmid (Human) - CHH3638 from Cohesion Biosciences
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POLR2F miRNA 3'UTR clone - MiUTR3H-06783 from Creative biogene
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