| Gene Symbol |
TTLL1
|
| Entrez Gene |
25809
|
| Alt Symbol |
C22orf7, HS323M22B
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
tubulin tyrosine ligase-like family member 1
|
| Other Description |
PGs3|catalytic subunit of neural tubulin polyglutamylase|probable tubulin polyglutamylase TTLL1|tubulin polyglutamylase complex subunit 3|tubulin tyrosine ligase-like family, member 1|tubulin--tyrosine ligase-like protein 1|tubulin-tyrosine ligase
|
| Swissprots |
B2RDS7 O95922 Q9NRS9 Q9UMU0 Q9BR27
|
| Accessions |
EAW73279 EAW73280 EAW73281 O95922 AF104927 AAG29879 AF173935 AAF91088 AI369631 AK095996 BAG53193 AK315658 BAG38024 AL096883 CAB51423 AL096886 CAB51469 AL136687 CAB66622 AL589867 CAC34478 BC009058 BC014968 AAH14968 BF433080 BG911167 CR456599 CAG30485 CU013199 CAK54630 CU013487 CAK54929 DA247656 DQ892198 ABM83124 DQ895393 ABM86319 XM_006724225 XP_006724288 XM_011530108 XP_011528410 XM_011530109 XP_011528411 XM_011530110 XP_011528412 NM_001008572 NM_012263 NP_036395 NR_027779
|
| Function |
Catalytic subunit of the neuronal tubulin polyglutamylase complex. Modifies alpha- and beta-tubulin, generating side chains of glutamate on the gamma-carboxyl groups of specific glutamate residues within the C-terminal tail of alpha- and beta-tubulin (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cytoplasm, cytoskeleton {ECO:0000305}.
|
| Tissue Specificity |
Expressed in a wide range of tissues. Has a stronger expression in heart, brain and testis. {ECO:0000269|PubMed:11054573}.
|
![Western Blot: TTLL1 Overexpression Lysate (Adult Normal) [NBL1-17417] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for TTLL1.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_1/11711_TTLL1%2520Overexpression%2520Lysate%2520%2528Adult%2520Normal%2529-Western%2520Blot-NBL1-17417-img0002.jpg)