Gene Symbol | ID1 |
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Entrez Gene | 3397 |
Alt Symbol | ID, bHLHb24 |
Species | Human |
Gene Type | protein-coding |
Description | inhibitor of DNA binding 1, dominant negative helix-loop-helix protein |
Other Description | DNA-binding protein inhibitor ID-1|class B basic helix-loop-helix protein 24|dJ857M17.1.2 (inhibitor of DNA binding 1, dominant negative helix-loop-helix protein)|inhibitor of differentiation 1 |
Swissprots | O00652 Q9H0Z5 Q5TE67 A8K537 Q9H109 Q16371 P41134 O00651 Q969Z7 E1P5L4 Q16377 Q5TE66 |
Accessions | AAC13882 AAC13883 EAW76432 EAW76433 EAW76434 P41134 AI304595 AK291152 BAF83841 AK313786 BC000613 AAH00613 BC012420 AAH12420 BG546814 BI768231 BM856018 BT007443 AAP36111 D13889 BAA02988 D13890 BAA02989 DA839689 DQ891293 ABM82219 DQ893342 ABM84268 DQ894477 ABM85403 DQ896657 ABM87656 EU176458 ABW03909 EU176468 ABW03919 EU176808 ABW03609 S78825 AAB35038 S78986 AAB35037 X77956 CAA54920 NM_002165 NP_002156 NM_181353 NP_851998 |
Function | Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Inhibits skeletal muscle and cardiac myocyte differentiation. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer (By similarity). {ECO:0000250}. |
Subcellular Location | Cytoplasm {ECO:0000250}. Nucleus. |
Top Pathways | TGF-beta signaling pathway, Hippo signaling pathway, Signaling pathways regulating pluripotency of stem cells, Rap1 signaling pathway |
Active human Id1 full length protein - ab134896 from Abcam
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Human Id1 full length protein - ab131964 from Abcam
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Human Id1 full length protein - ab156711 from Abcam
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Human Id1 full length protein - ab156341 from Abcam
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Id1 peptide - ab194824 from Abcam
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Id1 peptide - ab86654 from Abcam
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ID / ID1 Antibody Blocking Peptide - LS-E1177 from LifeSpan Bioscience
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Recombinant Human ID1 Protein - H00003397-P01 from Novus Biologicals
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ID1 Protein - NBP2-23138 from Novus Biologicals
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ID1-Antibody-Center-Blocking-peptide - BP11717c from Abgent, a WuXi AppTec company
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Human ID1 protein - orb191129 from Biorbyt
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Human ID1 protein - orb244283 from Biorbyt
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ID1 protein (His tag) - 80R-2751 from Fitzgerald
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ID1 Blocking Peptide - abx062766 from Abbexa
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ID1 / BHLHB24 (1-155, His-tag) - AR50870PU-N from Acris Antibodies
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ID1 / BHLHB24 (1-155, His-tag) - AR50870PU-S from Acris Antibodies
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ID1 / BHLHB24 - H00003397-P01-10 from Acris Antibodies
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ID1 / BHLHB24 - H00003397-P01-25 from Acris Antibodies
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ID1, 1-155aa, Human, His tag, E.coli - 01-P2046 from ARP American Research Products
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ID1 fusion protein - Ag13359 from Proteintech Group
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ID1 fusion protein - Ag24342 from Proteintech Group
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Recombinant Human ID1, GST-tagged - ID1-14041H from Creative Biomart
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Recombinant Human inhibitor of DNA binding 1, dominant negative helix-loop-helix protein, His-tagged - ID1-531H from Creative Biomart
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ID1 Blocking Peptide - CBP1572 from Cohesion Biosciences
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Recombinant human DNA-binding protein inhibitor ID-1 - CSB-EP010966HU CSB-BP010966HU CSB-MP010966HU from Cusabio
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