| Gene Symbol |
NRBP1
|
| Entrez Gene |
29959
|
| Alt Symbol |
BCON3, MADM, MUDPNP, NRBP
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
nuclear receptor binding protein 1
|
| Other Description |
multiple domain putative nuclear protein|myeloid leukemia factor 1 adaptor molecule|nuclear receptor-binding protein
|
| Swissprots |
Q96SU3 D6W558 Q53FZ5 B3KV40 Q9UHY1
|
| Accessions |
AAY14847 CAE89912 EAX00578 EAX00579 EAX00580 Q9UHY1 AF113249 AAF21967 AK001946 BAA91993 AK027538 BAB55185 AK092860 AK122664 BAG53652 AK130619 AK223136 BAD96856 AK225540 AK301345 BAG62893 AL136682 CAB66617 BC001221 AAH01221 BQ225378 BQ949042 DQ895815 ABM86741 EU176366 ABW03817 XM_005264274 XP_005264331 XM_006711999 XP_006712062 NM_013392 NP_037524
|
| Function |
May play a role in subcellular trafficking between the endoplasmic reticulum and Golgi apparatus through interactions with the Rho-type GTPases. Binding to the NS3 protein of dengue virus type 2 appears to subvert this activity into the alteration of the intracellular membrane structure associated with flaviviral replication. {ECO:0000269|PubMed:11956649, ECO:0000269|PubMed:15084397, ECO:0000303|PubMed:11956649}.
|
| Subcellular Location |
Cytoplasm, cell cortex {ECO:0000269|PubMed:11956649}. Endomembrane system {ECO:0000269|PubMed:11956649}. Cell projection, lamellipodium {ECO:0000269|PubMed:11956649}. Note=Colocalizes with activated RAC3 to endomembranes and at the cell periphery in lamellipodia.
|
| Tissue Specificity |
Ubiquitously expressed in all tissues examined with high levels in the testis. {ECO:0000269|PubMed:10843813}.
|
![Western Blot: NRBP1 Overexpression Lysate (Adult Normal) [NBL1-13787] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for NRBP1.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/4529_NRBP1%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-13787-img0002.jpg)