| Gene Symbol | LEP |
|---|---|
| Entrez Gene | 3952 |
| Alt Symbol | LEPD, OB, OBS |
| Species | Human |
| Gene Type | protein-coding |
| Description | leptin |
| Other Description | leptin (murine obesity homolog)|leptin (obesity homolog, mouse)|obese protein|obese, mouse, homolog of|obesity factor |
| Swissprots | O15158 P41159 Q56A88 |
| Accessions | AAC31660 AAX81413 AAY46797 BAA09787 BAA09839 CBI71013 EAL24315 EAW83640 P41159 AF008123 AAB63507 AK313553 BAG36329 BC060830 AAH60830 BC069323 AAH69323 BC069452 AAH69452 BC069527 AAH69527 BU752306 D49487 BAA08448 DA762132 HQ448411 ADQ32891 U18915 AAA60470 U43653 AAC50400 XM_005250340 XP_005250397 NM_000230 NP_000221 |
| Function | May function as part of a signaling pathway that acts to regulate the size of the body fat depot. An increase in the level of LEP may act directly or indirectly on the CNS to inhibit food intake and/or regulate energy expenditure as part of a homeostatic mechanism to maintain constancy of the adipose mass. |
| Subcellular Location | Secreted. |
| Top Pathways | Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, Adipocytokine signaling pathway, Non-alcoholic fatty liver disease (NAFLD), AMPK signaling pathway |