Gene Symbol | LEP |
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Entrez Gene | 3952 |
Alt Symbol | LEPD, OB, OBS |
Species | Human |
Gene Type | protein-coding |
Description | leptin |
Other Description | leptin (murine obesity homolog)|leptin (obesity homolog, mouse)|obese protein|obese, mouse, homolog of|obesity factor |
Swissprots | O15158 P41159 Q56A88 |
Accessions | AAC31660 AAX81413 AAY46797 BAA09787 BAA09839 CBI71013 EAL24315 EAW83640 P41159 AF008123 AAB63507 AK313553 BAG36329 BC060830 AAH60830 BC069323 AAH69323 BC069452 AAH69452 BC069527 AAH69527 BU752306 D49487 BAA08448 DA762132 HQ448411 ADQ32891 U18915 AAA60470 U43653 AAC50400 XM_005250340 XP_005250397 NM_000230 NP_000221 |
Function | May function as part of a signaling pathway that acts to regulate the size of the body fat depot. An increase in the level of LEP may act directly or indirectly on the CNS to inhibit food intake and/or regulate energy expenditure as part of a homeostatic mechanism to maintain constancy of the adipose mass. |
Subcellular Location | Secreted. |
Top Pathways | Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, Adipocytokine signaling pathway, Non-alcoholic fatty liver disease (NAFLD), AMPK signaling pathway |
Active cow Leptin full length protein - ab68482 from Abcam
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Active human Leptin full length protein - ab168049 from Abcam
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Active human Leptin protein fragment - ab119739 from Abcam
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Active human Leptin Triple Mutant full length protein - ab73583 from Abcam
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Active mouse Leptin full length protein - ab168090 from Abcam
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Active mouse Leptin full length protein - ab73534 from Abcam
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Active rat Leptin full length protein - ab157034 from Abcam
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Active rat Leptin full length protein - ab73532 from Abcam
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Active sheep Leptin full length protein - ab68575 from Abcam
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Human Leptin full length protein - ab13987 from Abcam
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Human Leptin full length protein - ab51273 from Abcam
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Human Leptin full length protein - ab194029 from Abcam
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Leptin full length protein - ab9827 from Abcam
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Mouse Leptin protein fragment - ab9750 from Abcam
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Rat Leptin full length protein - ab646 from Abcam
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Leptin Antibody Blocking Peptide - LS-E4364 from LifeSpan Bioscience
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Leptin Antibody Blocking Peptide - LS-E8097 from LifeSpan Bioscience
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Leptin Antibody Blocking Peptide - LS-E15343 from LifeSpan Bioscience
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Leptin Antibody Blocking Peptide - LS-E15344 from LifeSpan Bioscience
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Recombinant Human Leptin/OB Protein - NBP2-34934 from Novus Biologicals
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Leptin/OB Recombinant Protein - H00003952-P01 from Novus Biologicals
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Leptin/OB Recombinant Protein - P4102 from Novus Biologicals
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Leptin/OB Recombinant Protein - P4420 from Novus Biologicals
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Leptin/OB Protein - NBP1-99143 from Novus Biologicals
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Leptin/OB Protein - NBP1-99358 from Novus Biologicals
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