Gene Symbol | ZWILCH |
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Entrez Gene | 55055 |
Alt Symbol | KNTC1AP, hZwilch |
Species | Human |
Gene Type | protein-coding |
Description | zwilch kinetochore protein |
Other Description | Zwilch, kinetochore associated, homolog|homolog of Drosophila Zwilch|protein zwilch homolog |
Swissprots | Q96SY7 Q8N404 Q9NWG7 B3KVB8 Q9H900 Q6N049 |
Accessions | EAW77777 EAW77778 EAW77779 Q9H900 AK000898 AK023175 BAB14446 AK027468 BAB55133 AK122787 BAG53730 AK291048 BAF83737 BC036900 AAH36900 BC090041 AAH90041 BQ775697 BX640701 CAE45821 NR_003105 NM_001287821 NP_001274750 NM_001287822 NP_001274751 NM_001287823 NP_001274752 NM_017975 NP_060445 |
Function | Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. {ECO:0000269|PubMed:15824131}. |
Subcellular Location | Chromosome, centromere, kinetochore {ECO:0000269|PubMed:20462495}. |
Zwilch CRISPR/Cas9 KO Plasmid (h) - sc-418052 from Santa Cruz Biotechnology
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Zwilch HDR Plasmid (h) - sc-418052-HDR from Santa Cruz Biotechnology
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Zwilch Double Nickase Plasmid (h) - sc-418052-NIC from Santa Cruz Biotechnology
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Zwilch Double Nickase Plasmid (h2) - sc-418052-NIC-2 from Santa Cruz Biotechnology
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Zwilch CRISPR Activation Plasmid (h) - sc-418052-ACT from Santa Cruz Biotechnology
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Zwilch CRISPR Activation Plasmid (h2) - sc-418052-ACT-2 from Santa Cruz Biotechnology
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Zwilch Lentiviral Activation Particles (h) - sc-418052-LAC from Santa Cruz Biotechnology
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Zwilch Lentiviral Activation Particles (h2) - sc-418052-LAC-2 from Santa Cruz Biotechnology
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Zwilch siRNA (h) - sc-63261 from Santa Cruz Biotechnology
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Zwilch shRNA Plasmid (h) - sc-63261-SH from Santa Cruz Biotechnology
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Zwilch shRNA (h) Lentiviral Particles - sc-63261-V from Santa Cruz Biotechnology
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ZWILCH RNAi - H00055055-R03 from Novus Biologicals
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ZWILCH RNAi - H00055055-R02 from Novus Biologicals
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ZWILCH RNAi - H00055055-R01 from Novus Biologicals
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MISSION® esiRNA - EHU144991 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN23822 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND23822 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR08937 from Sigma-Aldrich
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ZWILCH siRNA (Human) - CRJ0435 from Cohesion Biosciences
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ZWILCH - MBS8212121 from MyBioSource
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shRNA set against Human ZWILCH (NM_017975.3) - SHH456128 from Creative biogene
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Human ZWILCH siRNA - orb270936 from Biorbyt
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ZWILCH shRNA Plasmid (Human) - CHJ0435 from Cohesion Biosciences
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ZWILCH miRNA 3'UTR clone - MiUTR1H-11771 from Creative biogene
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