| Gene Symbol |
PPP2R5C
|
| Entrez Gene |
5527
|
| Alt Symbol |
B56G, PR61G
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
protein phosphatase 2, regulatory subunit B', gamma
|
| Other Description |
B' alpha regulatory subunit|PP2A B subunit isoform B'-gamma|PP2A B subunit isoform B56-gamma|PP2A B subunit isoform PR61-gamma|PP2A B subunit isoform R5-gamma|protein phosphatase 2, regulatory subunit B (B56), gamma isoform|protein phosphatase 2, regulatory subunit B', gamma isoform|renal carcinoma antigen NY-REN-29|serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform
|
| Swissprots |
Q15174 F5GWP3 Q15060 Q14391 B5BUA5 Q6ZN33 B4DYJ8 Q13362
|
| Accessions |
AAL14777 AAL14778 AAL14779 EAW81752 EAW81753 EAW81754 EAW81755 EAW81756 EAW81757 Q13362 AA487513 AA716736 AB451341 BAG70155 AI282996 AI692258 AK131391 BAD18542 AK302470 BAG63760 AK315072 AL834350 BC016183 AAH16183 BC051442 BI560029 BQ006619 BX248254 CAD62582 D26445 BAA05465 DA853338 L42375 AAC37603 U37352 AAC50387 Z69030 CAA93154 XM_005267819 XP_005267876 XM_005267820 XP_005267877 XM_005267822 XP_005267879 XM_005267823 XP_005267880 XM_005267824 XP_005267881 XM_005267826 XP_005267883 XM_005267827 XP_005267884 XM_011536914 XP_011535216 XM_011536915 XP_011535217 XM_011536916 XP_011535218 XM_011536917 XP_011535219 XM_011536918 XP_011535220 XM_011536919 XP_011535221 XM_011536920 XP_011535222 XM_011536921 XP_011535223 NM_001161725 NP_001155197 NM_001161726 NP_001155198 NM_002719 NP_002710 NM_178586 NP_848701 NM_178587 NP_848702 NM_178588
|
| Function |
The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. The PP2A-PPP2R5C holoenzyme may specifically dephosphorylate and activate TP53 and play a role in DNA damage- induced inhibition of cell proliferation. PP2A-PPP2R5C may also regulate the ERK signaling pathway through ERK dephosphorylation. {ECO:0000269|PubMed:16456541, ECO:0000269|PubMed:17245430}.
|
| Subcellular Location |
Nucleus. Chromosome, centromere.
|
| Tissue Specificity |
Highest levels in heart, skeletal muscle and brain. Lower levels in pancreas, kidney, lung and placenta. Very low levels in liver.
|
| Top Pathways |
Oocyte meiosis, mRNA surveillance pathway, Dopaminergic synapse, PI3K-Akt signaling pathway, Adrenergic signaling in cardiomyocytes
|