| Gene Symbol |
SLC30A5
|
| Entrez Gene |
64924
|
| Alt Symbol |
ZNT5, ZNTL1, ZTL1, ZnT-5
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
solute carrier family 30 (zinc transporter), member 5
|
| Other Description |
zinc transporter 5|zinc transporter ZTL1|znT-like transporter 1
|
| Swissprots |
Q8TDG3 Q9H9H1 Q7L4M4 Q9BVY8 B7ZM89 Q8TAD4 Q6UX54
|
| Accessions |
EAW51307 EAW51308 EAW51309 EAW51310 Q8TAD4 AF212235 AAK14921 AF461760 AAL96437 AK022558 BAB14098 AK022818 BAB14258 AK292925 BAF85614 AL833716 AY089991 AAM09099 AY358505 AAQ88869 BC000808 AAH00808 BC003411 AAH03411 BC008198 AAH08198 BC017441 AAH17441 BC130452 AAI30453 BC130454 AAI30455 BC144349 AAI44350 BC148650 AAI48651 BC153202 AAI53203 BX537394 CAD97636 DB090660 DB259372 EU831923 ACE87364 EU832017 ACE86679 JF802034 AEG25670 XM_005248569 XP_005248626 XM_006714672 XP_006714735 NM_001251969 NP_001238898 NM_022902 NP_075053 NM_024055 NP_076960
|
| Function |
Functions as a zinc transporter. May be a transporter of zinc into beta cells in order to form insulin crystals. Partly regulates cellular zinc homeostasis. Required with ZNT7 for the activation of zinc-requiring enzymes, alkaline phosphatases (ALPs). Transports zinc into the lumens of the Golgi apparatus and vesicular compartments where ALPs locate, thus, converting apoALPs to holoALPs. Required with ZNT6 and ZNT7 for the activation of TNAP. {ECO:0000269|PubMed:11904301, ECO:0000269|PubMed:11937503, ECO:0000269|PubMed:15276077, ECO:0000269|PubMed:15525635, ECO:0000269|PubMed:15994300}.
|
| Subcellular Location |
Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:11904301, ECO:0000269|PubMed:11937503, ECO:0000269|PubMed:15525635}; Multi- pass membrane protein {ECO:0000269|PubMed:11904301, ECO:0000269|PubMed:11937503, ECO:0000269|PubMed:15525635}. Note=Perimeter of granules, localizes to the brush border membrane of the enterocyte. Concentrated in early compartments of the secretory pathway such as COPII-coated vesicles.
|
| Tissue Specificity |
Ubiquitously expressed. Highly expressed in pancreas, liver and kidney. Expressed abundantly in insulin- containing beta cells, undetectable in other endocrine cell types including glucagon-secreting alpha cells and most acinar cells. {ECO:0000269|PubMed:11904301, ECO:0000269|PubMed:11937503}.
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