Gene Symbol |
REG3G
|
Entrez Gene |
130120
|
Alt Symbol |
LPPM429, PAP IB, PAP-1B, PAP1B, PAPIB, REG III, REG-III, UNQ429
|
Species |
Human
|
Gene Type |
protein-coding
|
Description |
regenerating islet-derived 3 gamma
|
Other Description |
REG-3-gamma|pancreatitis-associated protein 1B|pancreatitis-associated protein IB|reg III-gamma|regenerating gene III|regenerating islet-derived protein 3-gamma|regenerating islet-derived protein III-gamma
|
Swissprots |
Q3SYE6 Q3SYE4 D6W5J6 Q6UW15 Q6FH18 A8K980
|
Accessions |
AAX88840 BAD51395 EAW99580 EAW99581 Q6UW15 AB161037 BAD51394 AB161038 BAD51396 AI025191 AK292595 BAF85284 AY359047 AAQ89406 AY428734 AAR88147 BC103852 AAI03853 BC103853 AAI03854 BC103854 AAI03855 BI792387 BX280299 CR541938 CAG46736 XM_005264135 XP_005264192 NM_001008387 NP_001008388 NM_001270040 NP_001256969 NM_198448 NP_940850
|
Function |
Bactericidal C-type lectin which acts exclusively against Gram-positive bacteria and mediates bacterial killing by binding to surface-exposed carbohydrate moieties of peptidoglycan. Restricts bacterial colonization of the intestinal epithelial surface and consequently limits activation of adaptive immune responses by the microbiota. The uncleaved form has bacteriostatic activity, whereas the cleaved form has bactericidal activity against L.monocytogenes and methicillin-resistant S.aureus. Regulates keratinocyte proliferation and differentiation after skin injury. {ECO:0000269|PubMed:19095652}.
|
Subcellular Location |
Secreted. Cytoplasm {ECO:0000250}.
|
Tissue Specificity |
Predominantly expressed in pancreas, where it may be restricted to exocrine pancreas. Moderate expression levels in testis and weak in heart, kidney and placenta. {ECO:0000269|PubMed:15556304, ECO:0000269|PubMed:15777617}.
|