Gene Symbol | MED6 |
---|---|
Entrez Gene | 10001 |
Alt Symbol | ARC33, NY-REN-28 |
Species | Human |
Gene Type | protein-coding |
Description | mediator complex subunit 6 |
Other Description | CTD-2540L5.5|activator-recruited cofactor 33 kDa component|mediator of RNA polymerase II transcription subunit 6|renal carcinoma antigen NY-REN-28 |
Swissprots | Q6FHQ4 B4DU17 O75586 B4E2P0 Q9UHL1 Q53FE3 Q9BTH1 O15401 Q53HJ3 |
Accessions | EAW81038 EAW81039 EAW81040 EAW81041 EAW81042 O75586 AF074723 AAC26869 AF155104 AAD42870 AK222587 BAD96307 AK223346 BAD97066 AK290647 BAF83336 AK300417 BAG62146 AK300460 BAG62179 AK304361 BAG65202 BC004106 AAH04106 BM152825 BM802752 BM999935 BT006831 AAP35477 CR541697 CAG46498 DA869309 HG506344 HY064772 U78082 AAB84363 NM_001284209 NP_001271138 NM_001284210 NP_001271139 NM_001284211 NP_001271140 NM_005466 NP_005457 |
Function | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. {ECO:0000269|PubMed:16595664}. |
Subcellular Location | Nucleus. |
Med6 CRISPR/Cas9 KO Plasmid (h) - sc-403204 from Santa Cruz Biotechnology
|
||||||||
Med6 HDR Plasmid (h) - sc-403204-HDR from Santa Cruz Biotechnology
|
||||||||
Med6 Double Nickase Plasmid (h) - sc-403204-NIC from Santa Cruz Biotechnology
|
||||||||
Med6 Double Nickase Plasmid (h2) - sc-403204-NIC-2 from Santa Cruz Biotechnology
|
||||||||
Med6 CRISPR Activation Plasmid (h) - sc-403204-ACT from Santa Cruz Biotechnology
|
||||||||
Med6 CRISPR Activation Plasmid (h2) - sc-403204-ACT-2 from Santa Cruz Biotechnology
|
||||||||
Med6 Lentiviral Activation Particles (h) - sc-403204-LAC from Santa Cruz Biotechnology
|
||||||||
Med6 Lentiviral Activation Particles (h2) - sc-403204-LAC-2 from Santa Cruz Biotechnology
|
||||||||
Med6 siRNA (h) - sc-38580 from Santa Cruz Biotechnology
|
||||||||
Med6 shRNA Plasmid (h) - sc-38580-SH from Santa Cruz Biotechnology
|
||||||||
Med6 shRNA (h) Lentiviral Particles - sc-38580-V from Santa Cruz Biotechnology
|
||||||||
MED6 RNAi - H00010001-R01 from Novus Biologicals
|
||||||||
MISSION® esiRNA - EHU021371 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit - CKOZFN13182 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND13182 from Sigma-Aldrich
|
||||||||
MISSION® 3′UTR Lenti GoClone™ - HUTR04644 from Sigma-Aldrich
|
||||||||
MED6 siRNA (Human) - CRH6729 from Cohesion Biosciences
|
||||||||
Med6 HDR Plasmid (h2) - sc-403204-HDR-2 from Santa Cruz Biotechnology
|
||||||||
Med6 CRISPR/Cas9 KO Plasmid (h2) - sc-403204-KO-2 from Santa Cruz Biotechnology
|
||||||||
shRNA set against Human MED6 (NM_005466.2) - SHH340131 from Creative biogene
|
||||||||
shRNA set against Human MED6(NM_005466.2) - SHH183679 from Creative biogene
|
||||||||
MED6 shRNA Plasmid (Human) - CHH6729 from Cohesion Biosciences
|
||||||||
MED6 miRNA 3'UTR clone - MiUTR1H-06192 from Creative biogene
|