| Gene Symbol |
NELFCD
|
| Entrez Gene |
51497
|
| Alt Symbol |
HSPC130, NELF-C, NELF-D, TH1, TH1L
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
negative elongation factor complex member C/D
|
| Other Description |
NELF-C/D|TH1 drosophila homolog|TH1-like protein|negative elongation factor C/D|negative elongation factor proteins C and D|trihydrophobin 1
|
| Swissprots |
Q9UGN2 Q9H405 B4DE06 Q9UGN1 Q9NVX5 Q8IXH7 Q9H8T3 Q9P029 Q9UGN3 Q9H888 Q9BYL2
|
| Accessions |
EAW75451 EAW75452 EAW75453 EAW75454 EAW75455 EAW75456 Q8IXH7 AA831111 AF161479 AAF29094 AJ238374 CAB64337 AJ238375 CAB64373 AJ238376 AJ238379 CAB64339 AK001316 BAA91618 AK023310 BAB14519 AK023927 BAB14729 AK127431 AK293410 BAG56917 AK304310 BAG65163 BC014952 AAH14952 BI459250 BM974193 BQ022435 BX647417 HY015074 JF432711 ADZ15928 XM_011528849 XP_011527151 XR_244142 NM_198976 NP_945327 NM_016397
|
| Function |
Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II. The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex. {ECO:0000269|PubMed:10199401, ECO:0000269|PubMed:12612062}.
|
| Subcellular Location |
Nucleus {ECO:0000305}.
|
| Tissue Specificity |
Widely expressed. Expressed in heart, brain, lung, placenta, liver, skeletal and cardiac muscle, adrenal, thyroid, kidney and pancreas. {ECO:0000269|PubMed:11030415, ECO:0000269|PubMed:12612062}.
|