| Gene Symbol | Ffar3 |
|---|---|
| Entrez Gene | 233080 |
| Alt Symbol | Gm478, Gpr41 |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | free fatty acid receptor 3 |
| Other Description | G protein-coupled receptor 41|G-protein coupled receptor 41|putative G protein-coupled receptor GPR41 |
| Swissprots | Q3UFD7 |
| Accessions | EDL23982 Q3UFD7 AK148616 BAE28624 BC109330 AAI09331 BC125009 AAI25010 NM_001033316 NP_001028488 |
| Function | G protein-coupled receptor that is activated by a major product of dietary fiber digestion, the short chain fatty acids (SCFAs), and that plays a role in the regulation of whole-body energy homeostasis and in intestinal immunity. In omnivorous mammals, the short chain fatty acids acetate, propionate and butyrate are produced primarily by the gut microbiome that metabolizes dietary fibers. SCFAs serve as a source of energy but also act as signaling molecules. That G protein-coupled receptor is probably coupled to the pertussis toxin-sensitive, G(i/o)-alpha family of G proteins. Its activation results in the formation of inositol 1,4,5-trisphosphate, the mobilization of intracellular calcium, the phosphorylation of the MAPK3/ERK1 and MAPK1/ERK2 kinases and the inhibition of intracellular cAMP accumulation. Activated by SCFAs and by beta-hydroxybutyrate, a ketone body produced by the liver upon starvation, it inhibits N-type calcium channels and modulates the activity of sympathetic neuro |
| Subcellular Location | Cell membrane; Multi-pass membrane protein. |
| Tissue Specificity | Expressed in white adipose tissue and skeletal muscle (at protein level). Abundantly expressed in sympathetic ganglia such as the superior cervical ganglion. Also expressed by intestinal endocrine cells. {ECO:0000269|PubMed:14722361, ECO:0000269|PubMed:18931303, ECO:0000269|PubMed:21518883, ECO:0000269|PubMed:22190648, ECO:0000269|PubMed:24748202}. |