Gene Symbol | TTLL6 |
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Entrez Gene | 284076 |
Alt Symbol | TTL.6 |
Species | Human |
Gene Type | protein-coding |
Description | tubulin tyrosine ligase-like family member 6 |
Other Description | tubulin polyglutamylase TTLL6|tubulin--tyrosine ligase-like protein 6 |
Swissprots | Q24KS9 Q24KB2 Q24L55 Q8N841 Q24KX1 Q24KB6 Q8IYW6 Q24L76 Q24KF3 Q8NA62 Q24KB1 Q24L13 Q24KJ5 C9J233 B4DZJ5 Q24KN7 |
Accessions | AAX86172 AAX86173 AAX86174 AAX86175 AAX86176 AAX86177 AAX86178 AAX86179 AAX86180 AAX86181 AAX86182 AAX86183 AAX86184 AAX86185 AAX86186 AAX86187 AAX86188 AAX86189 AAX86190 AAX86191 AAX86192 AAX86193 AAX86194 AAX86195 AAX86196 AAX86197 AAX86198 AAX86199 AAX86200 AAX86201 AAX86202 AAX86203 AAX86204 AAX86205 AAX86206 AAX86214 AAX86215 AAX86216 AAX86217 AAX86218 AAX86219 AAX86220 AAX86221 AAX86222 AAX86223 AAX86224 AAX86225 AAX86226 AAX86227 AAX86228 AAX86229 AAX86230 AAX86231 AAX86232 AAX86233 AAX86234 AAX86235 AAX86236 AAX86237 AAX86238 AAX86239 AAX86240 AAX86241 AAX86242 AAX86243 AAX86244 AAX86245 AAX86246 AAX86247 AAX86248 AAX86256 AAX86257 AAX86258 AAX86259 AAX86260 AAX86261 AAX86262 AAX86263 AAX86264 AAX86265 AAX86266 AAX86267 AAX86268 AAX86269 AAX86270 AAX86271 AAX86272 AAX86273 AAX86274 AAX86275 AAX86276 AAX86277 AAX86278 AAX86279 AAX86280 AAX86281 AAX86282 AAX86283 AAX86284 AAX86285 AAX86286 AAX86287 AAX86288 AAX86289 AAX86290 AAX86298 AAX86299 AAX86300 AAX86301 AAX86302 AAX86303 AAX86304 AAX86305 AAX86306 AAX86307 AAX86308 AAX86309 AAX86310 AAX86311 AAX86312 AAX86313 AAX86314 AAX86315 AAX86316 AAX86317 AAX86318 AAX86319 AAX86320 AAX86321 AAX86322 AAX86323 AAX86324 AAX86325 AAX86326 AAX86327 AAX86328 AAX86329 AAX86330 AAX86331 AAX86332 AAX86340 AAX86341 AAX86342 AAX86343 AAX86344 AAX86345 AAX86346 AAX86347 AAX86348 AAX86349 AAX86350 AAX86351 AAX86352 AAX86353 AAX86354 AAX86355 AAX86356 AAX86357 AAX86358 AAX86359 AAX86360 AAX86361 AAX86362 AAX86363 AAX86364 AAX86365 AAX86366 AAX86367 AAX86368 AAX86369 AAX86370 AAX86371 AAX86372 AAX86373 AAX86374 AAX86382 AAX86383 AAX86384 AAX86385 AAX86386 AAX86387 AAX86388 AAX86389 AAX86390 AAX86391 AAX86392 AAX86393 AAX86394 AAX86395 AAX86396 AAX86397 AAX86398 AAX86399 AAX86400 AAX86401 AAX86402 AAX86403 AAX86404 AAX86405 AAX86406 AAX86407 AAX86408 AAX86409 AAX86410 AAX86411 AAX86412 AAX86413 AAX86414 AAX86415 AAX86416 AAX86424 AAX86425 AAX86426 AAX86427 AAX86428 AAX86429 AAX86430 AAX86431 AAX86432 AAX86433 AAX86434 AAX86435 AAX86436 AAX86437 AAX86438 AAX86439 AAX86440 AAX86441 AAX86442 AAX86443 AAX86444 AAX86445 AAX86446 AAX86447 AAX86448 AAX86449 AAX86450 AAX86451 AAX86452 AAX86453 AAX86454 AAX86455 AAX86456 AAX86457 AAX86458 AAY28091 AAY28092 AAY28093 AAY28094 AAY28095 AAY28096 AAY28097 AAY28098 AAY28099 AAY28100 AAY28101 AAY28102 AAY28103 AAY28104 AAY28105 AAY28106 AAY28107 AAY28108 AAY28109 AAY28110 AAY28111 AAY28112 AAY28113 AAY28114 AAY28115 AAY28116 AAY28117 AAY28118 AAY28119 AAY28120 AAY28121 AAY28122 AAY28123 AAY28124 AAY28125 EAW94709 EAW94710 EAW94711 EAW94712 EAW94713 Q8N841 AK093127 BAC04066 AK097392 AK302952 BAG64107 AK310321 AL834151 CAH56366 BC033563 AAH33563 BC041368 JF432211 ADZ15428 NM_001130918 NP_001124390 NM_173623 NP_775894 |
Function | Polyglutamylase which preferentially modifies alpha- tubulin. Mediates tubulin polyglutamylation in cilia. Involved in the side-chain elongation step of the polyglutamylation reaction rather than in the initiation step (By similarity). {ECO:0000250}. |
Subcellular Location | Cell projection, cilium {ECO:0000269|PubMed:22246503}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:22246503}. Note=CEP41 is required for its transport between the basal body and the cilium. |
TTLL6 CRISPR/Cas9 KO Plasmid (h) - sc-405753 from Santa Cruz Biotechnology
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TTLL6 HDR Plasmid (h) - sc-405753-HDR from Santa Cruz Biotechnology
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TTLL6 Double Nickase Plasmid (h) - sc-405753-NIC from Santa Cruz Biotechnology
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TTLL6 Double Nickase Plasmid (h2) - sc-405753-NIC-2 from Santa Cruz Biotechnology
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TTLL6 CRISPR Activation Plasmid (h) - sc-405753-ACT from Santa Cruz Biotechnology
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TTLL6 CRISPR Activation Plasmid (h2) - sc-405753-ACT-2 from Santa Cruz Biotechnology
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TTLL6 Lentiviral Activation Particles (h) - sc-405753-LAC from Santa Cruz Biotechnology
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TTLL6 Lentiviral Activation Particles (h2) - sc-405753-LAC-2 from Santa Cruz Biotechnology
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TTLL6 siRNA (h) - sc-94117 from Santa Cruz Biotechnology
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TTLL6 shRNA Plasmid (h) - sc-94117-SH from Santa Cruz Biotechnology
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TTLL6 shRNA (h) Lentiviral Particles - sc-94117-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU045051 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN22204 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND22204 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR07010 from Sigma-Aldrich
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TTLL6 siRNA (Human) - CRJ6966 from Cohesion Biosciences
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TTLL6 - MBS8235185 from MyBioSource
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shRNA set against Human TTLL6 (NM_173623.3) - SHH437432 from Creative biogene
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TTLL6 shRNA Plasmid (Human) - CHJ6966 from Cohesion Biosciences
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TTLL6 miRNA 3'UTR clone - MiUTR4H-TG09491 from Creative biogene
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