Siah2

Gene Symbol Siah2
Entrez Gene 20439
Alt Symbol AA415433, Sinh2
Species Mouse
Gene Type protein-coding
Description seven in absentia 2
Other Description E3 ubiquitin-protein ligase SIAH2|mSiah2|seven in absentia homolog 2|siah-2
Swissprots Q06986
Accessions EDL35339 Q06986 AK139626 BAE24087 AK149316 BAE28809 BC058400 AAH58400 Z19581 CAA79632 NM_009174 NP_033200
Function E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates E3 ubiquitin ligase activity either through direct binding to substrates or by functioning as the essential RING domain subunit of larger E3 complexes. Mediates ubiquitination and proteasomal degradation of DYRK2 in response to hypoxia. Promotes monoubiquitination of SNCA (By similarity). Triggers the ubiquitin-mediated degradation of many substrates, including proteins involved in transcription regulation (POU2AF1, PML, NCOR1), a cell surface receptor (DCC), an antiapoptotic protein (BAG1), and a protein involved in synaptic vesicle function in neurons (SYP). It is thereby involved in apoptosis, tumor suppression, cell cycle, transcription and signaling processes. Has some overlapping function
Subcellular Location Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Predominantly cytoplasmic. Partially nuclear. {ECO:0000250}.
Tissue Specificity Widely expressed at low level in embryos and adults. Expressed in a specific population of germ cells within both the mouse ovary and testis. Absent in primordial oocytes but expressed in all growing oocytes, coincident with their recruitment from the pool of quiescent cells. Its level of expression increases as the oocytes mature. Expressed in Graafian follicles and in fertilized zygotes up until the two cell stage, a time of extensive maternal transcript degradation and zygotic gene activation. Expressed in the testis from postmeiotic spermatids. {ECO:0000269|PubMed:7895278, ECO:0000269|PubMed:8404535}.

SIAH-2 CRISPR/Cas9 KO Plasmid (m) - sc-422932 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

SIAH-2 HDR Plasmid (m) - sc-422932-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

SIAH-2 Double Nickase Plasmid (m) - sc-422932-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

SIAH-2 Double Nickase Plasmid (m2) - sc-422932-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

SIAH-2 CRISPR Activation Plasmid (m) - sc-422932-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

SIAH-2 CRISPR Activation Plasmid (m2) - sc-422932-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

SIAH-2 Lentiviral Activation Particles (m) - sc-422932-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

SIAH-2 Lentiviral Activation Particles (m2) - sc-422932-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

SIAH-2 siRNA (m) - sc-37498 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Mouse

SIAH-2 shRNA Plasmid (m) - sc-37498-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Mouse

SIAH-2 shRNA (m) Lentiviral Particles - sc-37498-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Mouse

MISSION® esiRNA - EMU028681 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN41167 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND41167 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

SIAH2 siRNA (Mouse) - CRM3714 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Mouse

SIAH2 - MBS8225944 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Mouse

shRNA set against Mouse Siah2 (NM_009174.3) - SHH407360 from Creative biogene

Category siRNA
Species Reactivities Mouse

shRNA set against Mouse Siah2(NM_009174.3) - SHR224952 from Creative biogene

Category siRNA
Species Reactivities Mouse

Mouse SIAH2 siRNA - orb283190 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Mouse

SIAH2 shRNA Plasmid (Mouse) - CHM3714 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Mouse

SIAH2 miRNA 3'UTR clone - MiUTR1M-10702 from Creative biogene

Species Reactivities Mouse
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