| Gene Symbol |
RSL1D1
|
| Entrez Gene |
26156
|
| Alt Symbol |
CSIG, L12, PBK1, UTP30
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ribosomal L1 domain containing 1
|
| Other Description |
CATX-11|cellular senescence inhibited gene protein|cellular senescence-inhibited gene protein|ribosomal L1 domain-containing protein 1
|
| Swissprots |
Q6PL22 Q9Y3Z9 B4DJ58 Q8IWS7 Q8WUZ1 D3DUG7 Q2M1T7 Q9HDA9 O76021
|
| Accessions |
EAW85133 EAW85134 EAW85135 O76021 AF074987 AF083127 AAF98239 AJ007398 CAA07491 AK000822 AK025446 AK295935 BAG58720 AL049999 CAB43231 AY154473 AAN46298 AY598331 AAT06742 BC009802 BC016362 AAH16362 BC017899 AAH17899 BC019069 AAH19069 BC070325 BC107782 AAI07783 BC112228 AAI12229 BC113699 AAI13700 BI856275 HQ258262 ADR83016 HQ258426 ADR83180 NM_015659 NP_056474
|
| Function |
Regulates cellular senescence through inhibition of PTEN translation. Acts as a pro-apoptotic regulator in response to DNA damage. {ECO:0000269|PubMed:18678645, ECO:0000269|PubMed:22419112}.
|
| Subcellular Location |
Nucleus, nucleolus {ECO:0000269|PubMed:11790298, ECO:0000269|PubMed:12429849, ECO:0000269|PubMed:18678645, ECO:0000269|PubMed:22419112}. Note=Colocalizes with ING1 in the nucleolus after UV stress. {ECO:0000269|PubMed:22419112}.
|
| Tissue Specificity |
Expressed at high intensities in the heart, skeletal muscle, and placenta. {ECO:0000269|PubMed:18678645, ECO:0000269|PubMed:9859858}.
|