| Gene Symbol | NUDT10 |
|---|---|
| Entrez Gene | 170685 |
| Alt Symbol | APS2, DIPP3-alpha, DIPP3a |
| Species | Human |
| Gene Type | protein-coding |
| Description | nudix (nucleoside diphosphate linked moiety X)-type motif 10 |
| Other Description | diadenosine 5',5'''-P1,P6-hexaphosphate hydrolase 3-alpha|diadenosine hexaphosphate hydrolase (AMP-forming)|diphosphoinositol polyphosphate phosphohydrolase 3-alpha|nucleoside diphosphate-linked moiety X motif 10|nudix motif 10 |
| Swissprots | Q86VK1 A8K7D7 Q86VR0 D3DX69 Q8NFP7 |
| Accessions | EAW89910 EAW89911 Q8NFP7 AF469196 AAM64113 AK291952 BAF84641 BC049383 AAH49383 BC050700 AAH50700 BX449265 CN399689 HQ448577 ADQ33055 NM_001304963 NP_001291892 NM_153183 NP_694853 |
| Function | Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate), suggesting that it may play a role in signal transduction. Also able to catalyze the hydrolysis of dinucleoside oligophosphates, with Ap6A and Ap5A being the preferred substrates. The major reaction products are ADP and p4a from Ap6A and ADP and ATP from Ap5A. Also able to hydrolyze 5-phosphoribose 1-diphosphate. |
| Subcellular Location | Cytoplasm {ECO:0000305|PubMed:12121577}. |
| Tissue Specificity | Mainly expressed in testis and, at lower level in brain. According to PubMed:12121577, it is widely expressed. {ECO:0000269|PubMed:12105228, ECO:0000269|PubMed:12121577}. |