| Gene Symbol | ALOX5 |
|---|---|
| Entrez Gene | 240 |
| Alt Symbol | 5-LO, 5-LOX, 5LPG, LOG5 |
| Species | Human |
| Gene Type | protein-coding |
| Description | arachidonate 5-lipoxygenase |
| Other Description | LOX-5|arachidonic 5-lipoxygenase alpha-10 isoform|arachidonic 5-lipoxygenase delta-10-13 isoform|arachidonic 5-lipoxygenase delta-13 isoform|arachidonic 5-lipoxygenase delta-p10 isoform|arachidonic acid 5-lipoxygenase|leukotriene A4 synthase |
| Swissprots | E5FPY7 B7ZLS0 E5FPY5 P09917 Q5JQ14 E5FPY8 |
| Accessions | AAA59522 AAA63212 EAW86642 EAW86643 P09917 AB208946 BAD92183 AK225603 AK315223 AW403395 BC034464 BC040450 BC130332 AAI30333 BC132677 AAI32678 BC143985 AAI43986 BC143986 BM153780 BQ003253 HM592258 ADR30798 HM592259 ADR30799 HM592260 ADR30800 HM592261 ADR30801 HQ258335 ADR83089 J03571 AAA65450 J03600 AAA36183 JQ728550 AFH78150 XM_011539564 XP_011537866 XM_011546981 XP_011545283 NM_000698 NP_000689 NM_001256153 NP_001243082 NM_001256154 NP_001243083 |
| Function | Catalyzes the first step in leukotriene biosynthesis, and thereby plays a role in inflammatory processes. {ECO:0000269|PubMed:21233389}. |
| Subcellular Location | Cytoplasm. Nucleus matrix. Nucleus membrane; Peripheral membrane protein. Note=Shuttles between cytoplasm and nucleus. Found exclusively in the nucleus, when phosphorylated on Ser-272. Calcium binding promotes translocation from the cytosol and the nuclear matrix to the nuclear envelope and membrane association. |
| Top Pathways | Toxoplasmosis, Ovarian steroidogenesis, Arachidonic acid metabolism |