ALOX5

Gene Symbol ALOX5
Entrez Gene 240
Alt Symbol 5-LO, 5-LOX, 5LPG, LOG5
Species Human
Gene Type protein-coding
Description arachidonate 5-lipoxygenase
Other Description LOX-5|arachidonic 5-lipoxygenase alpha-10 isoform|arachidonic 5-lipoxygenase delta-10-13 isoform|arachidonic 5-lipoxygenase delta-13 isoform|arachidonic 5-lipoxygenase delta-p10 isoform|arachidonic acid 5-lipoxygenase|leukotriene A4 synthase
Swissprots E5FPY7 B7ZLS0 E5FPY5 P09917 Q5JQ14 E5FPY8
Accessions AAA59522 AAA63212 EAW86642 EAW86643 P09917 AB208946 BAD92183 AK225603 AK315223 AW403395 BC034464 BC040450 BC130332 AAI30333 BC132677 AAI32678 BC143985 AAI43986 BC143986 BM153780 BQ003253 HM592258 ADR30798 HM592259 ADR30799 HM592260 ADR30800 HM592261 ADR30801 HQ258335 ADR83089 J03571 AAA65450 J03600 AAA36183 JQ728550 AFH78150 XM_011539564 XP_011537866 XM_011546981 XP_011545283 NM_000698 NP_000689 NM_001256153 NP_001243082 NM_001256154 NP_001243083
Function Catalyzes the first step in leukotriene biosynthesis, and thereby plays a role in inflammatory processes. {ECO:0000269|PubMed:21233389}.
Subcellular Location Cytoplasm. Nucleus matrix. Nucleus membrane; Peripheral membrane protein. Note=Shuttles between cytoplasm and nucleus. Found exclusively in the nucleus, when phosphorylated on Ser-272. Calcium binding promotes translocation from the cytosol and the nuclear matrix to the nuclear envelope and membrane association.
Top Pathways Toxoplasmosis, Ovarian steroidogenesis, Arachidonic acid metabolism

Phospho-5-Lipoxygenase (Ser271) Antibody - 3748 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from COS cells, transfected with 5-LO wild type or 5-LO (Ser271Ala), using Phospho-5-Lipoxygenase (Ser271) Antibody. The phospho-specificity of the antibody was verified by preincubating the antibody with no peptide (upper), with 5-LO (Ser271) non-phosphopeptide (middle) or 5-LO (Ser271) phosphopeptide (lower) prior to incubating the membrane.

Phospho-5-Lipoxygenase (Ser663) Antibody - 3749 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from COS cells, transfected with 5-LO wild type or GFP 5-LO (Ser663Ala), using Phospho-5-Lipoxygenase (Ser663) Antibody. The phospho-specificity of the antibody was verified by preincubating the antibody with no peptide (left), with 5-LO (Ser663) non-phosphopeptide (middle) or 5-LO (Ser663) phosphopeptide (right) prior to incubating the membrane.

5-Lipoxygenase (C49G1) Rabbit mAb - 3289 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone C49G1
Western blot analysis of extracts from human RL cells using 5-Lipoxygenase (49G1) Rabbit mAb.

5-LO (N-19) - sc-8885 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
5-LO (N-19): sc-8885. Immunoperoxidase staining of formalin fixed, paraffin-embedded human stomach tissue showing cytoplasmic staining of glandular cells. Kindly provided by The Swedish Human Protein Atlas (HPA) program.

5-LO (H-120) - sc-20785 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
5-LO (H-120): sc-20785. Western blot analysis of 5-LO expression in P388D1 whole cell lysate (A) and mouse spleen tissue extract (B).

5-LO (C-19) - sc-8886 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
5-LO (C-19): sc-8886. Immunoperoxidase staining of formalin fixed, paraffin-embedded human placenta tissue showing cytoplasmic staining of trophoblastic cells and decidual cells.

5-LO (33) - sc-136195 from Santa Cruz Biotechnology

Prices $279.00
Sizes 50 µg/0.5 ml
Host Mouse
Clonality Monoclonal
5-LO (33): sc-136195. Immunofluorescence staining of A-431 cells showing cytoplasmic and membrane localization.

p-5-LO (Ser 523) - sc-135685 from Santa Cruz Biotechnology

Prices $295.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
p-5-LO (Ser 523): sc-135685. Western blot analysis of 5-LO phosphorylation in untreated (A) and lambda protein phosphatase-treated (B) rat prefrontal cortex tissue extracts.

Anti-5 Lipoxygenase (phospho S271) antibody - ab59395 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-5 Lipoxygenase (phospho S271) antibody (ab59395) at 1/500 dilutionLane 1 : Extracts from HuvEc cells.Lane 2 : Extracts from HuvEc cells plus phosphopeptide.

Anti-5 Lipoxygenase (phospho S523) antibody - ab30573 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-5 Lipoxygenase (phospho S523) antibody (ab30573) at 1/1000 dilutionLane 1 : rat cortex lysateLane 2 : rat cortex lysate

Anti-5 Lipoxygenase antibody - ab59341 from Abcam

Prices $379.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-5 Lipoxygenase antibody (ab59341) at 1/500 dilutionLane 1 : Extracts from HuvEc cells without immunizing peptideLane 2 : Extracts from HuvEc cells containing immunizing peptideObserved band size : 78 kDa (why is the actual band size different from the predicted?)

Anti-ALOX5 / 5-Lipoxygenase Antibody (phospho-Ser523) - LS-C53471 from LifeSpan Bioscience

Prices $445.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of rat cortex lysate showing specific immunolabeling of the ~80k doublet of 5-LO phosphorylated at Ser523 (Control). The phosphospecificity of this labeling is shown in the second lane (lambda-phosphatase: lambda-Ptase). The blot is identical

Anti-ALOX5 / 5-LOX Antibody (phospho-Ser523) - LS-C178 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western blot of rat cortex lysate showing specific immunolabeling of the ~80k doublet of 5-LO phosphorylated at Ser523 (Control). The phosphospecificity of this labeling is shown in the second lane (lambda-phosphatase: lambda-phosphatase). The blot is ide

Anti-ALOX5 / 5-LOX Antibody (aa651-666) - LS-C54526 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Antibody (0.3 ug/ml) staining of Rat Stomach lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Anti-ALOX5 / 5-LOX Antibody (C-Terminus) - LS-C71728 from LifeSpan Bioscience

Prices $455.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-ALOX5 / 5-LOX Antibody (aa100-200) - LS-C71729 from LifeSpan Bioscience

Prices $455.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-ALOX5 / 5-LOX Antibody (phospho-Ser523) - LS-C130497 from LifeSpan Bioscience

Prices $695.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-ALOX5 / 5-LOX Antibody - LS-C137452 from LifeSpan Bioscience

Prices $265.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-ALOX5 / 5-LOX Antibody (aa100-200, Biotin) - LS-C141573 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-ALOX5 / 5-LOX Antibody (aa100-200, DY650) - LS-C141574 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-ALOX5 / 5-LOX Antibody (aa100-200, DY488) - LS-C141575 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-ALOX5 / 5-Lipoxygenase Antibody (aa100-200, HRP) - LS-C141576 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-ALOX5 / 5-LOX Antibody (aa100-200, DY550) - LS-C141577 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-ALOX5 / 5-LOX Antibody (C-Terminus, Biotin) - LS-C141578 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-ALOX5 / 5-LOX Antibody (C-Terminus, DY650) - LS-C141579 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
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