SLC3A2

Gene Symbol SLC3A2
Entrez Gene 6520
Alt Symbol 4F2, 4F2HC, 4T2HC, CD98, CD98HC, MDU1, NACAE
Species Human
Gene Type protein-coding
Description solute carrier family 3 (amino acid transporter heavy chain), member 2
Other Description 4F2 cell-surface antigen heavy chain|CD98 heavy chain|antigen defined by monoclonal antibody 4F2, heavy chain|antigen identified by monoclonal antibodies 4F2, TRA1.10, TROP4, and T43|lymphocyte activation antigen 4F2 large subunit|monoclonal antibody 44D7|solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2|solute carrier family 3 member 2
Swissprots P08195 Q13543
Accessions AAA35489 EAW74118 EAW74119 EAW74120 EAW74121 EAW74122 EAW74123 P08195 AA594112 AB018010 BAA84649 AF055031 AK025584 AK090758 AK094620 AK225304 AK304497 BAG65305 AK304685 BAG65456 AK308797 AK311592 AU143131 BC001061 AAH01061 BC003000 AAH03000 BE018712 BQ128156 BU556953 BX362778 BX443653 CA453972 CB138799 CB151304 CN302816 DC395235 EU832612 ACE87703 EU832683 ACE87015 J02769 AAA51540 J02939 AAA52497 J03569 AAA35536 NM_001012662 NP_001012680 NM_001012664 NP_001012682 NM_001013251 NP_001013269 NM_002394 NP_002385 NR_037193 NM_001012661 NM_001012663
Function Required for the function of light chain amino-acid transporters. Involved in sodium-independent, high-affinity transport of large neutral amino acids such as phenylalanine, tyrosine, leucine, arginine and tryptophan. Involved in guiding and targeting of LAT1 and LAT2 to the plasma membrane. When associated with SLC7A6 or SLC7A7 acts as an arginine/glutamine exchanger, following an antiport mechanism for amino acid transport, influencing arginine release in exchange for extracellular amino acids. Plays a role in nitric oxide synthesis in human umbilical vein endothelial cells (HUVECs) via transport of L-arginine. Required for normal and neoplastic cell growth. When associated with SLC7A5/LAT1, is also involved in the transport of L-DOPA across the blood-brain barrier, and that of thyroid hormones triiodothyronine (T3) and thyroxine (T4) across the cell membrane in tissues such as placenta. Involved in the uptake of methylmercury (MeHg) when administered as the L-cysteine or D,L-homocys
Subcellular Location Apical cell membrane; Single-pass type II membrane protein. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Localized to the plasma membrane when associated with SLC7A5 or SLC7A8. Localized to the placental apical membrane. Located selectively at cell-cell adhesion sites (By similarity). Colocalized with SLC7A8/LAT2 at the basolateral membrane of kidney proximal tubules and small intestine epithelia. Expressed in both luminal and abluminal membranes of brain capillary endothelial cells (By similarity). {ECO:0000250}.
Tissue Specificity Expressed ubiquitously in all tissues tested with highest levels detected in kidney, placenta and testis and weakest level in thymus. During gestation, expression in the placenta was significantly stronger at full-term than at the mid- trimester stage. Expressed in HUVECS and at low levels in resting peripheral blood T-lymphocytes and quiescent fibroblasts. Also expressed in fetal liver and in the astrocytic process of primary astrocytic gliomas. Expressed in retinal endothelial cells and in the intestinal epithelial cell line C2BBe1. {ECO:0000269|PubMed:11389679, ECO:0000269|PubMed:11557028, ECO:0000269|PubMed:11742812, ECO:0000269|PubMed:12716892, ECO:0000269|PubMed:14603368, ECO:0000269|PubMed:15980244, ECO:0000269|PubMed:16496379, ECO:0000269|PubMed:3265470, ECO:0000269|PubMed:3480538}.
Top Pathways Protein digestion and absorption

Human SLC3A2 / CD98 Heavy Chain ELISA Kit (Sandwich ELISA) - LS-F7798 from LifeSpan Bioscience

Category ELISA Kit
Prices $720.00
Sizes 1 plate
Sensitivity 0.061 ng/ml
Range 0.156-10 ng/ml

Human SLC3A2 / CD98 Heavy Chain ELISA Kit (Sandwich ELISA) - LS-F10685 from LifeSpan Bioscience

Category ELISA Kit
Prices $600.00
Sizes 1 plate
Sensitivity 0.156
Range 0.156-10 ng/ml

4F2 cell-surface antigen heavy chain (SLC3A2), Human, ELISA Kit - CSB-EL021640HU from ARP American Research Products

Category ELISA Kit
Prices $495.00, $695.00, $696.00, $699.00
Sizes 48 t, 96 t, 5 x 96t, 10 x 96t
Sensitivity 11.72 pg/ml
Range 46.88 pg/ml-3000 pg/ml

4F2 cell-surface antigen heavy chain, SLC3A2, Human, ELISA Kit - E2005h from ARP American Research Products

Category ELISA Kit
Prices $596.00
Sizes 96 t
Range 0.156-10 ng/mL

Large Neutral Amino Acid Transporter 1 (LAT1), Human, ELISA Kit - SEC005Hu from ARP American Research Products

Category ELISA Kit
Prices $720.00
Sizes 96 t
Sensitivity 0.056ng/mL
Range 0.156-10ng/mL

Solute Carrier Family 3, Member 2 (SLC3A2), Human, ELISA Kit - SEE348Hu from ARP American Research Products

Category ELISA Kit
Prices $720.00
Sizes 96 t
Sensitivity 0.051ng/mL
Range 0.156-10ng/mL

SLC3A2 (Human) Matched Antibody Pair - H00006520-AP21 from Acris Antibodies

Category Antibody Pair
Prices $610.00
Sizes 1 set

solute carrier family 3 (activators of dibasic and neutral amino acid transport) , member 2, ELISA Kit - MBS924027 from MyBioSource

Category ELISA Kit
Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00
Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity 11.72 pg/ml
Range 46.88 pg/ml-3000 pg/ml

4F2 cell-surface antigen heavy chain, ELISA Kit - MBS280470 from MyBioSource

Category ELISA Kit
Prices $465.00, $790.00, $3,500.00, $6,655.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

ELISA Kit for Solute Carrier Family 3, Member 2 (SLC3A2) - SEE348Hu from Uscn Life Science Inc.

Category ELISA Kit
Sensitivity The minimum detectable dose of this kit is typically less than 0.061ng/mL.
Range 0.156-10ng/mL The standard curve concentrations used for the ELISA’s were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

Human 4F2 cell-surface antigen heavy chain(SLC3A2) ELISA kit - CSB-EL021640HU from Cusabio

Category ELISA Kit
Sensitivity 11.72 pg/ml.
Range 46.88 pg/ml-3000 pg/ml

ELISA Kit for Solute Carrier Family 3, Member 2 (SLC3A2) - SEE348Hu from Cloud-clone

Category ELISA Kit
Sensitivity The minimum detectable dose of this kit is typically less than 0.061ng/mL.
Range 0.156-10ng/mL The standard curve concentrations used for the ELISA's were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

Rabbit SLC3A2 / CD98 Heavy Chain ELISA Kit - LS-F19024 from LifeSpan Bioscience

Category ELISA Kit
Prices $700.00
Sizes 1 plate
Sensitivity To be determined
Range To be determined

Mouse SLC3A2 / CD98 Heavy Chain ELISA Kit (Custom ELISA) - LS-F19022 from LifeSpan Bioscience

Category ELISA Kit
Prices $600.00
Sizes 1 plate
Sensitivity To be determined
Range 0.156-10 ng/ml

Rat SLC3A2 / CD98 Heavy Chain ELISA Kit (Custom ELISA) - LS-F19023 from LifeSpan Bioscience

Category ELISA Kit
Prices $600.00
Sizes 1 plate
Sensitivity To be determined
Range 0.156-10 ng/ml

Human 4F2 cell-surface antigen heavy chain ELISA Kit - abx251370 from Abbexa

Category ELISA Kit
Range 0.156 ng/ml - 10 ng/ml

Human SLC3A2 ELISA Kit - abx153110 from Abbexa

Category ELISA Kit
Sensitivity 0.051 ng/ml
Range 0.156 ng/ml - 10 ng/ml

Solute Carrier Family 3, Member 2 (SLC3A2), Human, ELISA Kit - DL-SLC3A2-Hu from ARP American Research Products

Category ELISA Kit
Prices $655.00
Sizes 96 t
Range 0.156-10 ng/mL

Human SLC3A2 ELISA Kit - abx571226 from Abbexa

Category ELISA Kit
Sensitivity 0.051 ng/ml
Range 0.156 ng/ml - 10 ng/ml

Human 4F2 cell-surface antigen heavy chain(SLC3A2) ELISA Kit - EKC32407 from Biomatik

Category ELISA Kit
Prices $705.00, $2,820.00, $5,287.50
Sizes 96 t, 5x96t, 10x96t
Sensitivity 11.72 pg/ml
Range 46.88 pg/ml-3000 pg/ml

Human 4F2 cell-surface antigen heavy chain ELISA Kit - EKE54077 from Biomatik

Category ELISA Kit
Prices $685.40, $2,912.95, $5,483.20
Sizes 96 t, 5x96t, 10x96t
Sensitivity The minimum detectable dose of this kit is typically less than 0.078 ng/mL
Range 0.156-10 ng/mL

SLC3A2 - EKH4084 from Nordic BioSite

Sensitivity 0.094ng/ml
Range 0.156-10ng/ml

SLC3A2 ELISA Kit (Human) (OKEH01425) - OKEH01425 from Aviva Systems Biology

Category ELISA Kit
Prices $420.00
Sizes 96 wells
Sensitivity < 0.078 ng/mL
Range 0.156 - 10 ng/mL

Human SLC3A2 ELISA Kit - E035998 from Biobool

Category ELISA Kit
Sensitivity 11.72 pg/ml

Human 4F2 cell-surface antigen heavy chain ELISA Kit - EK4177 from Signalway Antibody

Category ELISA Kit
Prices $599.00
Sizes 1x96t
Sensitivity less than 15.6 ng/mL
Range 62.5-4000 ng/mL
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