| Gene Symbol |
AMFR
|
| Entrez Gene |
267
|
| Alt Symbol |
GP78, RNF45
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
autocrine motility factor receptor, E3 ubiquitin protein ligase
|
| Other Description |
E3 ubiquitin-protein ligase AMFR|RING finger protein 45
|
| Swissprots |
P26442 Q9UKV5 Q8IZ70
|
| Accessions |
AAA79361 CAH05417 EAW82857 EAW82858 Q9UKV5 AA767223 AF124145 AAD56722 AK023874 AK123962 BC017043 AAH17043 BC051032 BC056869 AAH56869 BC069197 AAH69197 BX345849 BX409690 CA748782 DQ582721 L35233 AAA79362 M63175 AAA36671 W60999 XM_005255889 XP_005255946 XM_005255890 XP_005255947 NM_001144 NP_001135 NM_138958
|
| Function |
E3 ubiquitin-protein ligase that mediates the polyubiquitination of a number of proteins such as CD3D, CYP3A4, CFTR and APOB for proteasomal degradation. Component of a VCP/p97- AMFR/gp78 complex that participates in the final step of endoplasmic reticulum-associated degradation (ERAD). The VCP/p97- AMFR/gp78 complex is involved in the sterol-accelerated ERAD degradation of HMGCR through binding to the HMGCR-INSIG complex at the ER membrane and initiating ubiquitination of HMGCR. The ubiquitinated HMGCR is then released from the ER by the complex into the cytosol for subsequent destruction. Also acts as a scaffold protein to assemble a complex that couples ubiquitination, retranslocation and deglycosylation. Mediates tumor invasion and metastasis as a receptor for the GPI/autocrine motility factor. {ECO:0000269|PubMed:10456327, ECO:0000269|PubMed:11724934, ECO:0000269|PubMed:16168377, ECO:0000269|PubMed:19103148}.
|
| Subcellular Location |
Endoplasmic reticulum membrane {ECO:0000269|PubMed:11724934}; Multi-pass membrane protein {ECO:0000269|PubMed:11724934}.
|
| Top Pathways |
Protein processing in endoplasmic reticulum
|