| Gene Symbol |
Ube2d3
|
| Entrez Gene |
81920
|
| Alt Symbol |
-
|
| Species |
Rat
|
| Gene Type |
protein-coding
|
| Description |
ubiquitin-conjugating enzyme E2D 3
|
| Other Description |
E2(17)KB 3|PAPase|phosphoarginine phosphatase|ubiquitin carrier protein D3|ubiquitin-conjugating enzyme E2 D3|ubiquitin-conjugating enzyme E2(17)KB 3|ubiquitin-conjugating enzyme E2-17 kDa 3|ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast)|ubiquitin-conjugating enzyme E2D 3 (homologous to yeast UBC4/5)|ubiquitin-protein ligase D3
|
| Swissprots |
P61078 P47986
|
| Accessions |
EDL82261 EDL82262 EDL82263 EDL82264 EDL82265 EDL82266 EDL82267 P61078 AB006852 BAA87330 AY724500 BC072696 AAH72696 FQ215509 FQ226278 FQ233355 U13175 AAA85100 XM_006233333 XP_006233395 XM_006233334 XP_006233396 XM_006233335 XP_006233397 XM_006233336 XP_006233398 XM_006233337 XP_006233399 XM_006233338 XP_006233400 NM_031237 NP_112516
|
| Function |
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys- 11'-, as well as 'Lys-48'-linked polyubiquitination. Cooperates with the E2 CDC34 and the SCF(FBXW11) E3 ligase complex for the polyubiquitination of NFKBIA leading to its subsequent proteasomal degradation. Acts as an initiator E2, priming the phosphorylated NFKBIA target at positions 'Lys-21' and/or 'Lys-22' with a monoubiquitin. Ubiquitin chain elongation is then performed by CDC34, building ubiquitin chains from the UBE2D3-primed NFKBIA- linked ubiquitin. Acts also as an initiator E2, in conjunction with RNF8, for the priming of PCNA. Monoubiquitination of PCNA, and its subsequent polyubiquitination, are essential events in the operation of the DNA damage tolerance (DDT) pathway that is activated after DNA damage caused by UV or chemical agents during S-phase. Associates with the BRCA1/BARD1 E3 ligase complex to perform ubiquitination at DNA damage sites following
|
| Subcellular Location |
Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Endosome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
|
| Top Pathways |
Ubiquitin mediated proteolysis, Protein processing in endoplasmic reticulum
|