| Gene Symbol |
MIER1
|
| Entrez Gene |
57708
|
| Alt Symbol |
ER1, MI-ER1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
mesoderm induction early response 1, transcriptional regulator
|
| Other Description |
mesoderm induction early response 1 homolog|mesoderm induction early response protein 1
|
| Swissprots |
Q8NES4 Q08AE0 Q86TB4 Q5TAD5 Q5T104 Q5TAD2 Q6AHY8 C9JFD4 Q5TAD1 Q8WWG2 Q8N156 Q8N161 Q8NC37 Q9HCG2 Q32NC4 Q8N108 Q8NES5 Q5TAD4 Q8NES6
|
| Accessions |
CCQ43062 EAX06505 EAX06506 EAX06507 EAX06508 EAX06509 EAX06510 EAX06511 EAX06512 Q8N108 AB046830 BAB13436 AF515446 AAM76040 AF515447 AAM76041 AF515448 AAM76042 AK302061 BAG63451 AK307717 AL831987 CAD89921 AY124186 AAM97499 AY124187 AAM97500 AY124188 AAM97501 AY124189 AAM97502 AY124190 AAM97503 AY124191 AAM97504 AY124192 AAM97505 AY124193 AAM97506 AY124194 AAM97507 BC017423 AAH17423 BC066898 AAH66898 BC108726 AAI08727 BC125217 AAI25218 BC125218 AAI25219 BM987758 CR627441 CAH10526 XM_005271075 XP_005271132 XM_005271076 XP_005271133 XM_005271077 XP_005271134 XM_006710794 XP_006710857 XM_011541864 XP_011540166 XM_011541865 XP_011540167 XM_011541866 XP_011540168 XM_011541867 XP_011540169 NM_001077700 NP_001071168 NM_001077701 NP_001071169 NM_001077702 NP_001071170 NM_001077703 NP_001071171 NM_001077704 NP_001071172 NM_001146110 NP_001139582 NM_001146111 NP_001139583 NM_001146112 NP_001139584 NM_001146113 NP_001139585 NM_001278215 NP_001265144 NM_020948 NP_065999
|
| Function |
Transcriptional repressor regulating the expression of a number of genes including SP1 target genes. Probably functions through recruitment of HDAC1 a histone deacetylase involved in chromatin silencing. {ECO:0000269|PubMed:12482978}.
|
| Subcellular Location |
Isoform 5: Cytoplasm.
|
| Tissue Specificity |
Ubiquitously expressed, but at very low levels. However, consistent level of expression are observed in heart, testis, thyroid, ovary and adrenal gland. Transcripts are up-regulated in breast carcinoma cell lines and tumor. {ECO:0000269|PubMed:12242014, ECO:0000269|PubMed:9813250}.
|