| Gene Symbol |
SPARC
|
| Entrez Gene |
282077
|
| Alt Symbol |
-
|
| Species |
Bovine
|
| Gene Type |
protein-coding
|
| Description |
secreted protein, acidic, cysteine-rich (osteonectin)
|
| Other Description |
BM-40|ON|basement-membrane protein 40|osteonectin|secreted protein acidic and rich in cysteine
|
| Swissprots |
P13213 Q3B7N5 A5D9C9
|
| Accessions |
AAA51416 DAA27257 P13213 BC107529 AAI07530 BT030548 ABQ12988 J03233 AAA30678 M31318 AAA30677 NM_174464 NP_776889
|
| Function |
Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity.
|
| Subcellular Location |
Secreted, extracellular space, extracellular matrix, basement membrane {ECO:0000269|PubMed:2982834}. Note=In or around the basement membrane. {ECO:0000250}.
|
