| Gene Symbol |
SGOL1
|
| Entrez Gene |
151648
|
| Alt Symbol |
CAID, NY-BR-85, SGO, Sgo1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
shugoshin-like 1 (S. pombe)
|
| Other Description |
serologically defined breast cancer antigen NY-BR-85|shugoshin 1AB protein|shugoshin 1CD protein|shugoshin 1EF protein|shugoshin 1GH protein|shugoshin 1KL protein|shugoshin-like 1
|
| Swissprots |
Q5FBB4 Q9H275 Q5FBB8 Q5FBB5 Q8WVL0 Q5FBB7 Q8N579 Q9BVA8 Q5FBB6 Q588H5
|
| Accessions |
EAW64307 EAW64308 EAW64309 EAW64310 Q5FBB7 AB187577 BAD89587 AB187578 BAD89588 AB187579 BAD89589 AB187580 BAD89590 AB187581 BAD89591 AB187582 BAD89592 AB190994 BAD91318 AB193056 BAD95529 AB193057 BAD95530 AB193058 BAD95531 AB193059 BAD95532 AB193060 BAD95533 AB193061 BAD95534 AB193062 BAD95535 AB193063 BAD95536 AB193064 BAD95537 AB193065 BAD95538 AB193066 BAD95539 AB451340 BAG70154 AB451489 BAG70303 AB567656 BAJ79291 AB567657 BAJ79292 AF308299 AAG48266 AK024292 AK308095 BC001339 AAH01339 BC017867 AAH17867 BC032696 AAH32696 BC039605 BG530826 BM144963 BX494477 BX648516 DB163747 XM_011533373 XP_011531675 XM_011533374 XP_011531676 XM_011533375 XP_011531677 XM_011533376 XP_011531678 XM_011533377 XP_011531679 NM_001012409 NP_001012409 NM_001012410 NP_001012410 NM_001012411 NP_001012411 NM_001012412 NP_001012412 NM_001012413 NP_001012413 NM_001199251 NP_001186180 NM_001199252 NP_001186181 NM_001199253 NP_001186182 NM_001199254 NP_001186183 NM_001199255 NP_001186184 NM_001199256 NP_001186185 NM_001199257 NP_001186186 NM_138484 NP_612493 NR_131179 NR_131180
|
| Function |
Plays a central role in chromosome cohesion during mitosis by preventing premature dissociation of cohesin complex from centromeres after prophase, when most of cohesin complex dissociates from chromosomes arms. May act by preventing phosphorylation of the STAG2 subunit of cohesin complex at the centromere, ensuring cohesin persistence at centromere until cohesin cleavage by ESPL1/separase at anaphase. Essential for proper chromosome segregation during mitosis and this function requires interaction with PPP2R1A. Its phosphorylated form is necessary for chromosome congression and for the proper attachment of spindle microtubule to the kinetochore. Necessary for kinetochore localization of PLK1 and CENPF. May play a role in the tension sensing mechanism of the spindle-assembly checkpoint by regulating PLK1 kinetochore affinity. Isoform 3 plays a role in maintaining centriole cohesion involved in controlling spindle pole integrity. {ECO:0000269|PubMed:15604152, ECO:0000269|PubMed:15723797
|
| Subcellular Location |
Nucleus. Chromosome, centromere. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle pole. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Localizes to the inner centromere throughout prophase until metaphase and disappears at anaphase. During prometaphase, it localizes to a single focus, while at metaphase, it localizes to 2 spots corresponding to the 2 centromeres. Centromeric localization requires the presence of BUB1 and the interaction with PPP2R1A. Localizes to the inner kinetochore from prophase to early metaphase. Colocalizes with NEK2 and SS18L1 at the kinetochore. Phosphorylation by AUKRB and the presence of BUB1 are required for localization to the kinetochore. Isoform 1 primarily localizes to kinetochores during G2 phase and mitotic prophase, metaphase, and anaphase and does not appear to be associated with kinetochores during late mitosis. Isoform 3 is found at the centrosome in interphase and at spindle poles in mitosis and its s
|
| Tissue Specificity |
Widely expressed. Highly expressed in testis. Expressed in lung, small intestine, breast, liver and placenta. Strongly overexpressed in 90% of breast cancers tested. {ECO:0000269|PubMed:12747765}.
|
| Top Pathways |
Oocyte meiosis
|