| Gene Symbol |
KRTAP8-1
|
| Entrez Gene |
337879
|
| Alt Symbol |
KAP8.1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
keratin associated protein 8-1
|
| Other Description |
high glycine-tyrosine keratin-associated protein 8.1|keratin-associated protein 8-1
|
| Swissprots |
Q8IUC2 Q3LI57
|
| Accessions |
EAX09896 Q8IUC2 AB096961 BAE46376 AJ457064 CAD29720 BC130397 AAI30398 BC133033 AAI33034 NM_175857 NP_787053
|
| Function |
In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high- sulfur and high-glycine-tyrosine keratins.
|
| Tissue Specificity |
Is essentially restricted to only one vertical half of the hair forming compartment and in beard hairs is absent from the central medulla.
|